New thiamine nitrate synthesis process

Abstract

The invention discloses a new thiamine nitrate synthesis process, which is characterized in that a thiothiamine oxidizing liquid obtained by oxidizing with hydrogen peroxide is subjected to salt transformation with calcium nitrate to obtain a calcium sulfate solid, separation is performed, the salt transformation liquid is neutralized with ammonia water to obtain thiamine nitrate, separation is performed, the obtained mother liquor only contains ammonium sulfate, and three-effect evaporation is performed to obtain the pure ammonium sulfate. According to the present invention, with the new thiamine nitrate synthesis process, the traditional ammonium nitrate salt transformation method is improved, and the salt transformation is performed with calcium nitrate, such that the yield and the quality are not affected while the good effects can be provided for the components and the treatment of the late-stage mother liquor, the by-product calcium sulfate is generated, the pure ammonium sulfateis generated, and the problem of high ammonia nitrogen in the mother liquor in the traditional thiamine nitrate synthesis process can be solved.

Description

technical field [0001] The present invention relates to the synthetic technical field of thiamine nitrate, in particular to a new synthetic method of thiamine nitrate. Background technique [0002] Thiamine nitrate is the nitrate of vitamin B1. Vitamin B1 is a compound composed of pyrimidine ring and thiazole ring. Because the molecule contains sulfur and amine, it is also named thiamine. Vitamin B1 naturally exists in foods such as rice bran, bran, lean meat, and peanuts. The pure product is usually prepared by chemical synthesis and is a necessary nutrient for humans and animals. The lack of vitamin B1 can easily cause certain diseases. Commercially available vitamin B1 generally exists in two forms of its nitrate (thiamine nitrate) and hydrochloride (thiamine hydrochloride). Thiamine hydrochloride is commonly used as injection because of its stronger water solubility, general medical vitamin B1 is thiamine hydrochloride, and thiamine nitrate is often used as nutritional ...