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Preparation process of Eddy injection preparation

A technology for injection preparation and preparation process, applied in the field of preparation technology of Aidi injection preparation, can solve problems such as low incidence of adverse reactions and unsatisfactory extraction efficiency, and achieve the effects of reducing impurity content, ensuring effective retention, and improving extraction efficiency

Active Publication Date: 2018-04-20
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] With the improvement of living standards, the extraction efficiency of the existing Aidi injection preparation technology is not ideal, and in view of the gradual increase in the safety requirements for injection preparations, especially traditional Chinese medicine injection preparations, it is necessary to find a method with higher extraction efficiency and purity. The preparation process of Aidi injection preparations with high toxicity and low incidence of adverse reactions is a problem that medical workers need to solve at present

Method used

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  • Preparation process of Eddy injection preparation
  • Preparation process of Eddy injection preparation
  • Preparation process of Eddy injection preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Selection of raw materials: take 1.5g of Mylabris, 50g of Ginseng, 100g of Astragalus, and 150g of Acanthopanax;

[0048] (2) Extraction of ginseng: soak ginseng with 50% ethanol, heat and reflux for extraction twice, the first time for 3 hours, the second time for 1.5 hours, filter, recover the ethanol, and prepare the liquid for later use;

[0049] (3) Ginseng, Astragalus and Acanthopanax extraction: decoct the extracted ginseng dregs with Astragalus and Acanthopanax plus water for 3 times, the first time for 3 hours, the second time for 1.5 hours, the third time, each time 1 hour, filter, combine with the ginseng medicinal liquid obtained in step (2), and concentrate to 60-70° C. when the relative density is 1.15-1.20;

[0050] (4) Purification of Ginseng, Astragalus and Acanthopanax:

[0051] Alternative treatment of alcohol and water: add ethanol to the concentrated solution to adjust its alcohol content to 75%, refrigerate, filter, recover ethanol, then sink ...

Embodiment 2

[0059] (1) Selection of raw materials: take 1g of Mylabris, 30g of Ginseng, 80g of Astragalus, and 130g of Acanthopanax;

[0060] (2) Extraction of ginseng: soak ginseng with 30% ethanol, then heat and reflux extraction for 3 times, the first time for 2.5 hours, and then each time for 2 hours, filter, recover the ethanol, and prepare the liquid for later use;

[0061] (3) Ginseng, Astragalus and Acanthopanax extraction: decoct the extracted ginseng dregs with Astragalus and Acanthopanax plus water twice, for 2.5 hours for the first time, and 2 hours for the second time, filter, concentrate, and The ginseng medicinal liquid obtained in step (2) is combined and concentrated;

[0062] (4) Purification of Ginseng, Astragalus and Acanthopanax:

[0063] Alternative treatment of alcohol and water: add ethanol to the concentrated solution to adjust its alcohol content to 70%, refrigerate, filter, recover ethanol, then sink in water, filter and concentrate the water-sinking liquid, ad...

Embodiment 3

[0078] (1) Selection of raw materials: take 2g of mylabris, 80g of ginseng, 120g of astragalus, and 180g of Acanthopanax;

[0079] (2) Extraction of ginseng: soak ginseng in warm 80% ethanol, then heat and reflux for extraction twice, the first time for 4 hours, and then each time for 1 hour, filter, recover ethanol, and prepare the liquid for later use;

[0080] (3) Ginseng, Astragalus and Acanthopanax extraction: decoct the extracted ginseng dregs with Astragalus and Acanthopanax plus water 4 times, 4 hours for the first time, 1 hour for each time for 2-4 times, filter Over, concentrate, merge with step (2) gained ginseng liquid medicine, concentrate;

[0081] (4) Purification of Ginseng, Astragalus and Acanthopanax:

[0082] Alternate treatment of alcohol and water: Add ethanol to the concentrated solution to adjust its alcohol content to 80%, refrigerate, filter, recover ethanol, then sink in water, filter and concentrate the water-sinking liquid, add ethanol and alcohol-...

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Abstract

The invention relates to the field of medicine, in particular to a preparation process of an Eddy injection preparation. The preparation process of the Eddy injection preparation comprises the following steps: taking Chinese blister beetle, ginseng, astragalus membranaceus and acanthopanax as raw materials, performing warm dipping on the ginseng and performing alcohol extraction, jointly decoctingthe ginseng residues, the astragalus membranaceus and the acanthopanax and performing aqueous extraction, combining extraction liquid, performing alcohol and water precipitation alternately for manytimes and performing refrigeration treatment so as to completely precipitate and remove the impurities, greatly reduce the impurities in the medicine liquid and reduce the occurrence rate of adverse reaction, adjusting the pH, performing ultrafiltration and performing refrigeration for later use; performing warm dipping on the Chinese blister beetle and performing aqueous extraction, performing treatment by a lime surface method, performing alcohol precipitation for twice, refrigerating, filtering, performing water precipitation for twice, adjusting the pH, refrigerating and performing ultrafiltration; and mixing the Chinese blister beetle extracting liquid, the extracting liquid of the ginseng, the astragalus membranaceus and the acanthopanax, adding auxiliary materials and adjusting thepH. The preparation process of the Eddy injection preparation has the advantages of high extraction efficiency, high purity and low occurrence rate of adverse reaction.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a preparation process of Aidi injection preparation. Background technique [0002] Traditional Chinese medicine injection preparations are sterilized preparations made from Chinese medicinal materials through extraction, separation, refining and other steps. It has changed the traditional way of administering traditional Chinese medicine. It has rapid drug effect, high bioavailability, and more accurate dosage. It is suitable for cases that are not suitable for oral administration or acute and severe cases. It has played a good role in the treatment of acute, severe and difficult diseases by traditional Chinese medicine. However, with the increasing clinical application, the incidents of adverse drug reactions caused by traditional Chinese medicine injections have occurred frequently, which has attracted the attention of the majority of medical workers. The ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/08A61P35/00A61K35/64
CPCA61K9/0019A61K9/08A61K36/254A61K36/258A61K36/481A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K35/63A61K2300/00
Inventor 窦啟玲杨青波陆煜玫段毅邹安林
Owner GUIZHOU YIBAI PHARMA CO LTD
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