A method for preparing Longmu Zhuanggu Granules by ultra-high pressure extraction

A technology of bone strengthening and ultra-high pressure, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, bone diseases, etc., to achieve the effects of increasing transfer rate, improving drug efficacy, and improving clarity

Active Publication Date: 2020-05-08
JIANMIN PHARMA GRP CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the extraction and preparation of Longmu Zhuanggu Granules by ultra-high pressure method until now.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for preparing Longmu Zhuanggu Granules by ultra-high pressure extraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: the same as the prescription of CN 104147344A Example 1.

[0029] Preparation method: 1) Take Codonopsis pilosula, Astragalus membranaceus, Ophiopogon japonicus, Tortoise shell, Atractylodes macrocephala, Chinese yam, Schisandra chinensis, keel, oyster, Poria cocos, jujube, licorice, and gallinaceous gold, and grind the above medicinal materials together to a powder with a particle size of 50 meshes, and then press Add water to 12 times the total weight of the medicinal material and soak for 1 hour, then put the medicinal material and water together into a plastic bag and seal it, put it into the extraction container of the ultra-high pressure extraction device, and perform ultra-high pressure extraction at room temperature. The extraction procedure is as follows:

[0030] A boost stage: raise the pressure in the extraction vessel to 400Mpa within 15 minutes;

[0031] B holding stage: keep the pressure for 20 minutes;

[0032] C pressure relief stage: qui...

Embodiment 2

[0037] Prescription: the same as the prescription of CN 104147344A Example 1.

[0038] Preparation method: 1) Take Codonopsis pilosula, Astragalus membranaceus, Ophiopogon japonicus, Tortoise shell, Atractylodes macrocephala, Chinese yam, Schisandra chinensis, keel, oyster, Poria cocos, jujube, licorice, and gallinaceous gold, and grind the above medicinal materials together to a powder with a particle size of 60 meshes, and then press Add water to 8 times the total weight of the medicinal material and soak for 2 hours, then put the medicinal material and water together into a plastic bag and seal it, put it into the extraction container of the ultra-high pressure extraction device, and perform ultra-high pressure extraction at room temperature. The extraction procedure is as follows:

[0039] A boost stage: raise the pressure in the extraction container to 600Mpa within 30min;

[0040] B holding stage: keep the pressure for 10 minutes;

[0041] C pressure relief stage: quick...

Embodiment 3

[0046] Prescription: the same as the prescription of CN 104147344A Example 1.

[0047] Preparation method: 1) Take Codonopsis pilosula, Astragalus membranaceus, Ophiopogon japonicus, Tortoise shell, Atractylodes macrocephala, Chinese yam, Schisandra chinensis, keel, oyster, Poria cocos, jujube, licorice, and gallinaceous gold, and grind the above medicinal materials together to a powder with a particle size of 40 meshes, and then press Add water to 15 times the total weight of the medicinal material and soak for 0.5 hours, then put the medicinal material and water together into a plastic bag and seal it, put it into the extraction container of the ultra-high pressure extraction device, and perform ultra-high pressure extraction at room temperature. The extraction procedure is as follows:

[0048] A boost stage: raise the pressure in the extraction vessel to 300Mpa within 10 minutes;

[0049] B holding stage: keep the pressure for 30 minutes;

[0050] C pressure relief stage: ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for preparing fossil fragments and oyster bone strengthening particles by ultrahigh-pressure extracting. The method comprises the following steps: crushing codonopsispilosula, astragalus membranaceus, radix ophiopogonis, tortoise shell, rhizoma atractylodis macrocephalae, Chinese yam, schisandra chinensis, fossil fragments, oyster, poria cocos, fructus jujubae, liquorice and endothelium corneum gigeriae galli; soaking in water for a while; and then extracting through ultrahigh pressure, wherein the ultrahigh-pressure extracting process includes the steps of increasing the pressure, maintaining the pressure, and releasing the pressure. Compared with an existing extracting method, the method has the advantages that the content of active components in an extractive can be increased, and impurities can be decreased; and meanwhile, the transfer rate of the active components can be increased, so that the extracting can be completely carried out; the pharmacodynamics activity of the fossil fragments and oyster bone strengthening particles prepared by the method is improved.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a preparation method of Longmu Zhuanggu Granules, in particular to a method for preparing Longmu Zhuanggu Granules by ultra-high pressure extraction. Background technique [0002] CN1466976A discloses a medicine for preventing and treating rickets and osteoporosis and a preparation method thereof. The medicine belongs to a compound preparation of Chinese and Western medicines, and is compatible with Chinese medicines for invigorating the spleen and invigorating the kidney, so as to exert the effects of invigorating the spleen and stomach, and strengthening tendons and bones. It is used for the treatment and prevention of rickets and rickets in children. The drug has a clinical application history of more than 20 years. It is an exclusive product of Jianmin Pharmaceutical Group Co., Ltd., and its trade name is Longmu Zhuanggu Granules. "Longmu" is a well-known trademark in China, and Longmu ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/16A61P19/10A61P3/02A61K35/586A61K35/02A61K35/618A61K35/57A61K31/592A61K31/191
CPCA61K31/191A61K31/592A61K35/02A61K35/57A61K35/586A61K35/618A61K36/076A61K36/284A61K36/344A61K36/481A61K36/484A61K36/57A61K36/725A61K36/79A61K36/8945A61K36/8968A61K2236/37A61K2300/00
Inventor 黄志军赵刚方胡彪任霞余丽花向阳
Owner JIANMIN PHARMA GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap