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A kind of extraction method of Abamectin

A technology of abamectin and extraction method, which is applied in the direction of chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the problems of cumbersome process steps, high product loss rate, and large solvent consumption, and achieve process simplification and cost-effectiveness. The effect of good phase and strong solubility

Active Publication Date: 2021-02-12
NINGXIA TAIYICIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process steps are cumbersome, the solvent consumption is large, the product loss rate is high, and the purity is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Extraction: take 50m of abamectin fermentation broth 3 , the potency is 6897U / ml, and the total billion is 344.9kg. The avermectin fermentation liquid was filtered by plate and frame filtration, and the obtained mycelium filter residue was crushed, and then extracted by dynamic ultrasonic extraction. The ultrasonic extraction time was 40min, the extraction frequency was 3kHz, the extraction temperature was 75°C, and the extraction solvent was ethanol , the dosage is 2.6 times of mycelium weight.

[0016] Washing with water: After evaporating the ethanol in the extract to dryness, dissolve it with sec-butyl acetate, wash with hot water, leave to stand and separate layers, evaporate the solvent from the sec-butyl acetate phase, and obtain a paste. The consumption of sec-butyl acetate is 0.7 times of mycelium weight.

[0017] Extraction: The paste is extracted by two-phase extraction method, so that abamectin is distributed to the upper phase (glycol phase). The two-pha...

Embodiment 2

[0020] Extraction: take 50m of abamectin fermentation broth 3 , the potency is 6932U / ml, and the total billion is 346.6kg. The avermectin fermentation liquid was filtered by plate and frame filtration, the obtained mycelium filter residue was crushed, and then extracted by dynamic ultrasonic extraction. The ultrasonic extraction time was 45min, the extraction frequency was 4kHz, the extraction temperature was 75°C, and the extraction solvent was ethanol , the dosage is 3 times of mycelium weight.

[0021] Washing with water: After evaporating the ethanol in the extract to dryness, dissolve it with sec-butyl acetate, wash with hot water, leave to stand and separate layers, evaporate the solvent from the sec-butyl acetate phase, and obtain a paste. The consumption of sec-butyl acetate is 0.8 times of mycelium weight.

[0022] Extraction: The paste is extracted by two-phase extraction method, so that abamectin is distributed to the upper phase (glycol phase). The two-phase aqu...

Embodiment 3

[0025] Extraction: take 50m of abamectin fermentation broth 3 , the potency is 6996U / ml, and the total billion is 349.8kg. The avermectin fermentation liquid was filtered by plate and frame filtration, and the obtained mycelium filter residue was crushed, and then extracted by dynamic ultrasonic extraction. The ultrasonic extraction time was 50min, the extraction frequency was 5kHz, the extraction temperature was 80°C, and the extraction solvent was ethanol , the dosage is 3.5 times of mycelium weight.

[0026] Washing with water: After evaporating the ethanol in the extract to dryness, dissolve it with sec-butyl acetate, wash with hot water, leave to stand and separate layers, evaporate the solvent from the sec-butyl acetate phase, and obtain a paste. The amount of sec-butyl acetate is 1 time of mycelium weight.

[0027] Extraction: The paste is extracted by two-phase extraction method, so that abamectin is distributed to the upper phase (glycol phase). The two-phase aqueo...

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Abstract

The invention relates to a method for extracting abamectin. The process steps are: filter the abamectin fermented liquid with a plate and frame, pulverize the obtained mycelium filter residue, and then use a dynamic ultrasonic extraction method to extract, and steam the obtained extract After drying the solvent, dissolve it with sec-butyl acetate, wash with hot water, let it stand for stratification, and concentrate the sec-butyl acetate phase to obtain a paste, which is extracted by two-phase extraction method, and finally crystallized by gradient cooling That's it. The present invention adopts the dynamic ultrasonic extraction method to carry out the extraction of avermectin, compared with the original process, the process is simplified, the operation is simple, the solvent consumption is reduced, the cost is saved, the extraction efficiency can be improved at the same time, and the total yield of the product has been improved, and Compared with the product obtained by the original process, the purity is higher.

Description

technical field [0001] The invention belongs to the technical field of antibiotic extraction, in particular to an extraction method of abamectin. Background technique [0002] Abamectin is a widely used agricultural or veterinary fungicide, insecticide, and acaricide, also known as ametin. The traditional extraction process of abamectin is to filter the fermented liquid through plate and frame, and extract twice with ethanol after crushing the filter residue, evaporate the extract to dryness, dissolve it with butyl acetate, wash with water, and then concentrate to obtain a paste. The solid was dissolved in ethanol, crystallized twice, and then centrifuged and dried to obtain the product. The process steps are cumbersome, the solvent consumption is large, the product loss rate is high, and the purity is low. Contents of the invention [0003] The purpose of the present invention is just to overcome the defective of above-mentioned prior art, a kind of simplified technique...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/08
CPCC07H1/08C07H17/08
Inventor 梁丽娟刘鹏于荣曾淑云宋鲁宁
Owner NINGXIA TAIYICIN BIOTECH CO LTD