Arachis hypogaea L. nerve-soothing oral liquid and preparing method and application thereof
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A technology of oral liquid and groundnut branches and leaves, which is applied in the fields of pharmaceutical formulations, dispersion liquid delivery, nervous system diseases, etc., can solve problems such as research on effective chemical components that do not have the sedative and hypnotic effects of groundnut branches and leaves, and achieve the effect of increasing the content
Inactive Publication Date: 2018-06-22
SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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[0003] From 1973 to 1983, the United States and Japan had two papers on the chemical constituents of peanut branches and leaves. After 1987, there were 1-2 pharmacological research reports on the sedative and hypnotic effects of groundnut branches and leaves in China. Until June 2001, there were no Any report on the study of the effective chemical constituents of the sedative-hypnotic effect of groundnut branches and leaves
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Embodiment 1
[0018] Embodiment 1 Pharmacological screening of index components of groundnut branches and leaves
[0019] There is no relevant literature report on the research on the chemical constituents of groundnut branches and leaves for treating insomnia. In order to establish the index compounds of Arachis twigs and leaves, we worked closely with the Pharmacology Department of Shanghai Staff Medical College to screen the active substances.
[0020] Take 2 kg of chopped groundnut branches and leaves, add 20 times the amount of water and boil for 1 hour, filter the decoction, add 10 times the amount of water and boil for 1 hour, filter the decoction, combine the second decoction, and concentrate under reduced pressure in a 70°C water bath to 2000ml, add n-butanol 0.8L x 2 times, extract 0.4L x 1 time, wash the n-butanol extract with 250ml deionized water x 2 times, then concentrate at 70°C under reduced pressure to dryness, dry at 70°C in vacuum, weigh 32 grams.
[0021] The aqueous ...
Embodiment 2
[0064] Embodiment 2 The research of Luohua Anshen oral liquid preparation technology
[0065] 1. Research on raw material extraction process
[0066] 1.1 Identification and pretreatment of medicinal materials
[0067] 〔Peanut branches and leaves〕
[0068] This product is the dry aerial part of Arachis hypogaea L., a leguminous plant. There are not many studies on the chemical constituents of Arachis branches and leaves [5,10]. Water, alcohol, petroleum ether and other extracts of groundnut branches and leaves have sedative and hypnotic effects [7]. "National Compilation of Chinese Herbal Medicine" records that 60g of groundnut fresh leaves are fried into 15-20ml and taken orally before going to bed, which has sedative and hypnotic effects. A recent study by the research group found that the amino acid content of the branches and leaves of groundnut with strong pharmacological sedative and hypnotic effects is higher, and the total nitrogen content is still about 2% after al...
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Abstract
The invention relates to arachis hypogaea L. nerve-soothing oral liquid and a preparing method and application thereof. The preparing method of the arachis hypogaea L. nerve-soothing oral liquid comprises the following steps of taking ramulus et folium arachis hypogaea L., adding 10-fold water to conduct soaking for 2-4 h, conducting decocting twice, and adding 10-fold water for the second time, wherein decocting is conducted for 1 h every time; filtering decoction liquid, merging filtrates to be concentrated to the relative density of 1.15-1.20, chilling, adding ethyl alcohol to make the alcohol content reach 60%, uniformly stirring the mixture, standing for 24 h, filtering to obtain liquid supernatant, recycling ethyl alcohol in the filtrate till the filtrate has no smell of alcohol, adding water and uniformly stirring the filtrate, standing for 24 h, taking the liquid supernatant to be filtered, adding distillate, saccharose and sodium benzoate to be dissolved, adjusting the relative density to 1.07-1.10, conducting cold storage and standing for 48 h, filtering, adding water to the filtrate, boiling under the sealed condition, and filling and sterilizing to obtain the arachis hypogaea L. nerve-soothing oral liquid. By means of the arachis hypogaea L. nerve-soothing oral liquid and the preparing method and application thereof, active components of ramulus et folium arachis hypogaea L.for treating anhypnia are sifted and serve as indexes, and the optimum preparing technology of the arachis hypogaea L. nerve-soothing oral liquid preparation is sifted out.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to Luohua Anshen Oral Liquid and its preparation method and application. Background technique [0002] In 1988, Professor Wang Qiaochu, a nationally famous old Chinese doctor, guided by the theory of "correspondence between man and nature" in traditional Chinese medicine and the law of the growth and decline of yin and yang in nature, found that the phenomenon of falling peanut leaves and the human body "sleep at night and sleep at night" was consistent, and proposed that the two may have something in common. The idea (hypothesis) of the material basis, thus organizing the research group to conduct systematic research on the clinical efficacy and related pharmacy of groundnut branches and leaves in the treatment of insomnia. At present, Luohua Anshen Oral Liquid is an in-hospital preparation in Shanghai Hospital of Traditional Chinese Medicine, which tr...
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