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Application of metrnl in prevention and treatment of ulcerative colitis

A potential technology for ulcerative colitis, applied in the field of molecular biology and biomedicine, to achieve the effect of small side effects and high safety

Active Publication Date: 2020-09-08
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there is no report about the application of Metrn1 protein in the prevention and treatment of ulcerative colitis

Method used

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  • Application of metrnl in prevention and treatment of ulcerative colitis
  • Application of metrnl in prevention and treatment of ulcerative colitis
  • Application of metrnl in prevention and treatment of ulcerative colitis

Examples

Experimental program
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Effect test

Embodiment

[0037] 1. Method

[0038] 1. Animals: Metrnl intestinal epithelial-specific knockout mice and corresponding control wild-type mice were used, with 9 to 12 mice in each group. For the breeding methods of these mice, please refer to the applied patent (application number 201610458874.0) and published Literature (ActaPharmacol Sin. 2016 Aug 22. doi:10.1038 / aps. 2016. 70. [Epub ahead of print]).

[0039] 2. Administration of dextran sulfate sodium (DSS): DSS (molecular weight 36,000-50,000) from MP Company was used to prepare a 3% concentration and administered by free drinking to prepare a DSS-induced ulcerative colitis model .

[0040]3. Overall index detection: body weight is measured at 10 o'clock in the morning every day, and the weight change is scored (0 points for weight gain and change within 1%, 1 point for change of 1%-5%, 1 point for change of 5% -10% is 2 points, a change of 10%-15% is 3 points, and a change of more than 15% is 4 points); observe the mouse feces and...

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Abstract

The invention relates to application of Metrnl in preventing and treating ulcerative colitis. According to the application, a DSS (Dextran Sulfate Sodium) induced ulcerative colitis model is established by using Metrnl intestinal epithelium specific knock-out mice and corresponding reference wild mice, and results show that the Metrnl intestinal epithelium specific knock-out mice are suffered fromulcerative colitis which is conspicuously more serious than that of the reference wild mice, the intestinal mucosa erosion degrees of the Metrnl intestinal epithelium specific knock-out mice are conspicuously higher than those of the reference wild mice, and a Metrnl protein can be used as a novel effective medicine for preventing and treating ulcerative colitis. The invention provides a novel method for preventing and treating ulcerative colitis, and in addition, since the Metrnl protein self is an endogenous protein of human bodies, the Metrnl protein has very small possible side effects onhuman bodies and is very high in security as a potential medicine.

Description

technical field [0001] The invention relates to the fields of molecular biology and biomedicine, in particular to the application of Metrn1 in preventing and treating ulcerative colitis. Background technique [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD), also known as enteritis, is a group of recurrent inflammatory bowel diseases. Inflammatory bowel disease mainly includes two types: Crohn's disease (CD) and ulcerative colitis (UC). In developed countries, the incidence of IBD has reached 1 / 1000. In China, the total number of cases of inflammatory bowel disease in the past ten years is about 350,000. It is worth noting that the number of patients with this disease is increasing year by year. Compared with the previous 10 years, the total number of cases of inflammatory bowel disease has increased by more than 24 times, and the number of patients with Crohn's disease has even increased by more than 15 times. Ulcerative colitis lesions are mainly loc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K48/00A61K45/00A61P1/04C12Q1/6883
CPCA61K38/185A61K45/00A61K48/005C12Q1/6883C12Q2600/136
Inventor 缪朝玉张赛龙李志勇缪竹威
Owner THE NAVAL MEDICAL UNIV OF PLA
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