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Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

A kind of technology of morpholino methyl and indoline, applied in utilizing 3-(4-((4-(morpholinomethyl) benzyl)oxy)-1-oxoisoindoline In the field of cancer treatment with dol-2-yl)piperidine-2,6-dione, it can solve the problem of lack of response to rituximab

Active Publication Date: 2018-07-06
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

High J-chain expression in rheumatoid arthritis (RA) patients predicts lack of response to rituximab

Method used

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  • Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

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Embodiment Construction

[0116] Provided herein is a method for treating, managing or preventing cancer, comprising treating or preventing an effective amount of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisobis Indolin-2-yl)piperidine-2,6-dione or its enantiomer or mixture of enantiomers or its pharmaceutically acceptable salt, solvate, hydrate, co-crystal, A clathrate or polymorph is administered to a patient in need of such treatment, management or prevention as a single agent or as part of a combination therapy. In some embodiments, the compound is (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl ) piperidine-2,6-dione. In some embodiments, the compound is (R)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl ) piperidine-2,6-dione.

[0117] In certain embodiments, 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1 -Oxoisoindolin-2-yl)piperidine-2,6-dione or its enantiomer or mixture of enantiomers or its pharmaceutically acceptable salt, solvate, hydrate Compounds, co-crystal...

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Abstract

Provided herein are methods of treating, preventing and / or managing cancers, which comprise administering to a patient 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Description

[0001] The application date is August 08, 2013, the application number is 201380052496.0, and the name is "using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxo Substituted isoindolin-2-yl)piperidine-2,6-dione as a divisional application for the invention of "method for treating cancer". [0002] This application claims priority to U.S. Provisional Application No. 61 / 681,447, filed August 9, 2012, and U.S. Provisional Application No. 61 / 722,727, filed November 5, 2012, which are hereby incorporated by reference in their entirety . 1. Technical field [0003] Provided herein are methods of treating, preventing and / or managing cancer comprising administering to a patient 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindoline Indol-2-yl)piperidine-2,6-dione or its enantiomer or mixture of enantiomers or its pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate substances or polymorphs. 2. Background of the invention [0004] 2.1 Cancer Pathology [0005] C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61P35/00A61P35/02G01N33/574
CPCA61K31/5377A61K45/06A61P35/00A61P35/02A61P43/00A61K31/573A61K39/395A61K9/0053A61K9/48C07D413/14G01N33/50
Inventor 彼得·H·谢弗阿尼塔·甘地
Owner CELGENE CORP