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Antibacterial compound and purification preparation method and application thereof

A technology for compounds and antibacterial drugs, applied in the field of medicinal chemistry, can solve the problems such as the reduction of the probability of new medicinal microbial strains and new antibiotics, and achieve good development prospects and good inhibitory activity.

Active Publication Date: 2018-07-17
BINZHOU MEDICAL COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After decades of in-depth excavation, the probability of discovering new medicinal microbial strains and new antibiotics from ordinary habitats has been greatly reduced, while m

Method used

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  • Antibacterial compound and purification preparation method and application thereof
  • Antibacterial compound and purification preparation method and application thereof
  • Antibacterial compound and purification preparation method and application thereof

Examples

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Embodiment 1

[0023] Embodiment 1: the preparation of antibacterial compound:

[0024] Streptomyces griseus was streak-inoculated on ISP2 semi-seawater solid medium, cultured at 28°C for 3 days, a small amount of bacteria was inoculated into ISP2 semi-seawater liquid medium, cultured on a shaking table at 28°C at 180rpm for 10 days, and the fermentation product was harvested. Filtrate the fermentation product to obtain fermentation broth and mycelium, extract the fermentation broth through XAD-16 macroporous adsorption resin column, crush and extract the mycelium with acetone, concentrate the extract under reduced pressure, extract with ethyl acetate after combination, and concentrate under reduced pressure to obtain total extract. The total extract is subjected to silica gel column chromatography, and gradient elution is carried out to collect methanol: dichloromethane is 5:95 (volume ratio) of the eluted components, and the collected eluted components are subjected to ODS reverse-phase co...

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Abstract

The invention provides an antibacterial compound and a purification preparation method thereof. The compound is prepared by purifying from a streptomyces and can be used for preparing an antibacterialdrug and a biological pesticide. Studies show that the compound has broad-spectrum antibacterial activity, can significantly inhibit the growth of fungi and bacteria, and has the value of the development of new antibacterial drugs.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to an antibacterial compound, its purification and preparation method, and its application in the preparation of antibacterial drugs and biological pesticides. Background technique [0002] Due to the abuse of antibiotics, drug-resistant bacteria and infections caused by drug-resistant bacteria, especially Gram-negative drug-resistant bacteria, have reached an unprecedented level worldwide, and the therapeutic effect of original antibiotics has been greatly reduced. New diseases The rapid discovery of highly efficient and high-quality new antibiotics has become an important topic all over the world. Antibiotics are secondary metabolites of medicinal microorganisms represented by actinomycetes, and the discovery of new medicinal microbial resources, including new species, is one of the foundations for the discovery of new antibiotics. After decades of in-depth excavation, the prob...

Claims

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Application Information

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IPC IPC(8): C07D491/107A61P31/10A61P31/04A01N43/90A01P3/00A01P1/00C12P17/18C12R1/545
CPCA01N43/90C07D491/107C12P17/18
Inventor 张淑敏谢则平郭琳杨小平杨芹冯玲玲张露
Owner BINZHOU MEDICAL COLLEGE