Medical implant based on nanocellulose

A technology of implants and microbial cellulose, which is applied in the field of medical implants based on nanocellulose, to achieve the effects of avoiding infection, fully fitting, and easy to manufacture

Active Publication Date: 2018-07-17
耶拿大学综合医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, not every patient has a suitable vein, and to obtain the

Method used

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  • Medical implant based on nanocellulose
  • Medical implant based on nanocellulose
  • Medical implant based on nanocellulose

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0137] B) Example 1: Preparation of an implant

[0138] a) Preparation of BNC tube:

[0139] as in WO 2013 / 113675 A1 figure 1 The apparatus and reactor shown and described were used to prepare BNC tubes. To prepare the product, a plurality of stick molds are arranged in a jig and embedded in the moving parts of the device. The reactor is then closed and sterilized. After sterilizing the entire reactor, the reservoir of the reactor is filled under aseptic conditions with a mixture of cellulose-producing microorganisms and separately sterilized culture broth.

[0140] Then, start the unit's engine and perform the following steps:

[0141] - immersing the mold in the mixture of cellulose-producing microorganisms and culture fluid in the reservoir, thereby contacting the surface of the mold,

[0142] - removing the mold from the reservoir, thereby interrupting the contact between the mold and the mixture, wherein a liquid film comprising the liquid medium and the microorganis...

example 2

[0157] C) Example 2: Insertion of an implant in an animal to regenerate a bile duct.

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Abstract

The present invention provides a medical Implant (100). The medical Implant (100) comprises: a microbial cellulose tube (1) comprising a wall (2) having an inner surface (3) and an outer surface (4),wherein the wall comprises several layers (5, 6, 7) of microbial cellulose, the layers are concentric or substantially concentric to a longitudinal axis (L) of the tube; and a stent (9) which placed inside of the microbial cellulose tube (1), wherein an outer surface (10) of the stent contacts the inner surface (3) of the microbial cellulose tube (1), and method for producing such implant. The implant can be covered with newly created bile duct epithelium, thereby creating a new bile duct from body cells. The implant can be removed after completion of creation of the new bile duct. So, the implant as suitable as a temporary implant. The implant can be used for surgery, such as surgery of gall bladder, bile duct and/or liver, e.g. gall bladder removal, hepatobiliary malignancy surgery or liver transplantation. The implant can particularly be used for repairing or regeneration of bile duct. Further fields of use are the use as esophagus implant or urether implant.

Description

technical field [0001] The invention relates to a medical implant, in particular for repairing bile ducts, and a method for manufacturing such an implant. Background technique [0002] Reconstructing the bile duct is often a critical issue in hepatobiliary surgery because the absence of bile duct material often forces the surgeon to perform high-risk procedures or procedures such as biliary-enteric anastomosis. Such material loss or damage may occur when the gallbladder is removed with incidental damage to the common bile duct, or when the damage is caused by ischemia, eg, after liver transplantation or tumor resection. [0003] Reconstruction of such injuries is complex. In most cases, a so-called "bilioenterostomy," which is a connection between the common bile duct and part of the gastrointestinal tract, must be performed. During this procedure, a loop of intestine connects to the common bile duct. The fundamental problem with this approach is to bypass the sphincter m...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L31/10A61L31/14
CPCA61L31/005A61L31/10A61L31/146A61L2400/12A61L2420/08C08L1/00A61F2/04A61F2002/044A61F2002/041A61F2240/004A61F2240/005A61L2430/22C08L1/02
Inventor F·劳赫富斯U·塞特马赫尔D·克莱姆W·弗里德T·里希特K·佩措尔德-韦尔克C·鲁厄
Owner 耶拿大学综合医院
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