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Application of tristilbeside in the preparation of medicines for treating and/or preventing inflammatory bowel disease

A technology of trizaperidin and inflammatory bowel disease, which is applied in the application field of medicine, can solve the problems such as the use of inflammatory bowel disease medicine that has not been reported, so as to reduce colonic mucosal congestion, improve bloody stool, increase weight and activity sexual effect

Active Publication Date: 2019-12-13
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current studies have shown that trizaperine has anti-inflammatory, antibacterial, anti-oxidant, anti-cancer, treatment of depression and cardiovascular and cerebrovascular diseases and other active applications, but it has not been used in the treatment and prevention of inflammatory bowel disease drugs. Use report

Method used

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  • Application of tristilbeside in the preparation of medicines for treating and/or preventing inflammatory bowel disease
  • Application of tristilbeside in the preparation of medicines for treating and/or preventing inflammatory bowel disease
  • Application of tristilbeside in the preparation of medicines for treating and/or preventing inflammatory bowel disease

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The efficacy test proved the preventive effect of trizaperidin on the mouse ulcerative colitis model:

[0023] 1 Reagents and Animals

[0024] 1.1 Test product: Tristilbene raw material, Kunming Pharmaceutical Group Co., Ltd., traits: white powder; batch number: 20150407; storage conditions: room temperature, dark;

[0025] 1.2 Reference substance: sulfasalazine (SASP, the earliest salicylic acid preparation used in the treatment of IBD), Meilun Biology, traits: yellow powder; batch number: A0322A; storage conditions: room temperature, dark;

[0026] 1.3 Other reagents: dextran sodium sulfate (DSS) was purchased from MP Biomedicals.LLC (France); sodium carboxymethylcellulose was purchased from Tianjin Guangfu Institute of Fine Chemicals; mouse TNF-αELISA detection kit (Lianke Biological , Lot: 228271215); mouse IL-6 ELISA detection kit (Lianke Bio, Lot: 220680144);

[0027] 1.4 Experimental animals: SPF grade BALB / c mice, 40 males, body weight: 18±2g, provided by Shan...

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Abstract

The invention relates to the technical field of medicine, in particular to application of piceatannol 3'-O-glucoside in preparation of medicines for treating and / or preventing inflammatory bowel diseases. By means of a prevention and treatment test of the piceatannol 3'-O-glucoside for ulcerative colitis of mice, a BALB / c mouse DSS induction method is used for constructing a model so as to evaluate the effect of the 50mg / kg piceatannol 3'-O-glucoside and 100mg / kg piceatannol 3'-O-glucoside on resisting the ulcerative colitis of the mice. The results prove that the piceatannol 3'-O-glucoside can obviously reduce the hemafecia of the mice, reduces a colon weight / length ratio and hyperemia of the colonic mucosa, and increases body weight and activity. Therefore, the piceatannol 3'-O-glucosidehas the characteristics of high efficiency and low toxicity in the aspect of treating or preventing the inflammatory bowel diseases, thus having wide development and application values.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of trizaperine in the preparation of medicines for treating and / or preventing inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a special chronic intestinal inflammatory disease, mainly including ulcerative colitis (Ulcerative colitis, UC) and Crohn's disease (Crohns disease, CD). According to literature reports, the number of IBD cases in my country in the past five years is 8-10 times that of the same period in the 1990s, and it has become the main cause of common diseases of the digestive system and chronic diarrhea. Clinically, IBD patients present with repeated abdominal pain, diarrhea, mucus and bloody stools, and even various systemic complications such as blurred vision, joint pain, and rashes. The onset of IBD is rare and rapid, and most of them are slow, and the course of the disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P1/00A61P29/00A61P7/10
CPCA61K31/7034A61P1/00A61P7/10A61P29/00
Inventor 任超王萍黄茜郑晓琼张建文
Owner KPC PHARM INC
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