Rare earth-organic porous material, preparation method thereof and application thereof in detection of nerve disease marker glutamic acid

A technology of porous materials and rare earths, applied in the field of fluorescent probes for detecting neurological disease marker glutamate, can solve the problems of time-consuming detection, complicated operation, expensive instruments, etc., and achieve the effects of good stability, simple process and mild conditions
CN108456218AActive Publication Date: 2018-08-28ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2018-08-28

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Abstract

The invention relates to a rare earth-organic porous material, a preparation method thereof and application thereof in the detection of nerve disease marker glutamic acid. Through the technical scheme, the preparation method comprises the following steps: dissolving Ln(NO3)3.6H2O, hydroxyterephthalic acid and 2-fluorobenzoic acid into a mixed solution of an organic solvent, water and nitric acid;sealing after ultrasonic uniformity, putting the mixture in a baking oven at the temperature of 110 DEG C for 3 d; naturally cooling to room temperature, washing, filtering and drying to obtain the rare earth-organic porous material. The rare earth-organic porous material prepared in the invention has obvious fluorescent response to the nerve disease marker glutamic acid, rare earth luminescence is taken as an interior label, the luminescence of organic molecules is taken as a detection signal, high-selective detection for glutamic acid can be realized, and then the material can be used for early prevention and diagnosis of nerve diseases.
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Description

technical field

[0001] The present invention relates to a kind of preparation method and application of rare earth-organic porous material, specifically, relate to Ln 3+ (Ln=Eu, Tb, Gd) and hydroxyterephthalic acid-structured rare earth-organic porous material are used as fluorescent probes for detecting neurological disease marker glutamic acid. Background technique

[0002] Glutamate (Glu) is an important excitatory neurotransmitter, which plays an important role in the normal functional activities and neuromodulation of the central nervous system. Glutamate carries out its own transport and signal transduction through a large number of "carriers" to complete the regulation of the physiological and pathological state of the body, so it is closely related to the occurrence of many diseases. The increase of glutamate concentration indicates the possible occurrence of some neuropathies, such as acute ischemic stroke, Parkinson's disease, epilepsy and Alzheimer's disease, so ...

Claims

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