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A composition for predicting irinotecan chemotherapy toxicity biomarkers

A technique for irinotecan, chemotherapy toxicity, applied in the field of predicting biomarkers

Active Publication Date: 2020-11-27
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Serum metabolite levels have not been used to predict individual differences in irinotecan chemotherapy toxicity

Method used

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  • A composition for predicting irinotecan chemotherapy toxicity biomarkers
  • A composition for predicting irinotecan chemotherapy toxicity biomarkers
  • A composition for predicting irinotecan chemotherapy toxicity biomarkers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] The composition and exact content of the biomarker combination used to predict irinotecan delayed diarrhea are shown in Table 2:

[0104] Table 2 Differential metabolites predicting delayed diarrhea sensitive vs non-sensitive

[0105]

Embodiment 2

[0107] The combination of biomarkers used to predict irinotecan myelosuppression, its composition and accurate content are shown in Table 3: Table 3 predicts the differential metabolites of myelosuppression-sensitive vs non-sensitive

[0108]

[0109]

Embodiment 3

[0111] A composition predictive of sensitivity to irinotecan chemotherapy toxicity, the ratio of each component being:

[0112] Glycocholic acid: 2.04~2.86;

[0113] Phenylalanine: 55.23~69.07;

[0114] Cholic acid: 24.44~34.12;

[0115] Deoxycholic acid: 1.72~2.52;

[0116] And, or, unit: any one of μmol, μmol / L.

[0117] The use of the composition is: take the composition as a reference substance, detect the content of the above four substances in the sample, so as to predict the sensitivity of the organism to the chemotherapy toxicity of irinotecan.

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Abstract

The invention relates to a biomarker set for predicting the severity of tardive diarrhea and marrow inhibitive capability after medicine application. Compared with non-sensitive individuals with the slight degree of tardive diarrhea after medicine application, the serum of sensitive individuals with the severe degree of tardive diarrhea is obviously high in cholic acid content, deoxycholic acid content and glycocholic acid content and obviously low in phenylalanine content before medicine application. Compared with non-sensitive individuals with the slight degree of marrow inhibitive capability after medicine application, the serum of sensitive individuals with the severe degree of marrow inhibitive capability is obviously high in glycocholic acid content and low in phenylalanine content,lysine content and tryptophan content before medicine application.

Description

technical field [0001] The present invention relates to the field of predictive biomarkers, in particular to a composition of a group of biomarkers predicting irinotecan chemotherapy toxicity, the composition is derived from serum endogenous small molecule metabolites, and the composition is useful for rapid prediction of individual response to irinotecan The sensitivity of rinotecan and clinical individualized treatment are of great significance. Background technique [0002] Irinotecan (CPT-11) is a DNA topoisomerase I inhibitor mainly used in the first-line treatment of metastatic colorectal cancer. Studies have shown that irinotecan has severe chemotherapy toxicity in clinical use, mainly including delayed diarrhea and bone marrow suppression, which have become the main factors limiting its clinical application. [0003] There are obvious individual differences in the toxicity of irinotecan chemotherapy. Therefore, predicting the sensitivity of patients to irinotecan be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/50G01N30/02
CPCG01N30/02G01N33/5014G01N33/5088
Inventor 许风国高一乔陈佳青张尊建
Owner CHINA PHARM UNIV