Method and kit for establishing beagle heart insufficiency model

Abstract

The invention provides a method and kit for establishing a beagle heart insufficiency model. The kit is characterized by comprising premixed powder for intravenous drip or injection containing premixed powder for intravenous drip, the premixed powder for intravenous drip is composed of doxorubicin hydrochloride, omeprazole sodium and bacillus licheniformis, the concentration of the premixed powderfor intravenous drip in the injection containing the premixed powder for intravenous drip is 0.4 mg / mL, and the mass ratio of the doxorubicin hydrochloride to the omeprazole sodium to the bacillus licheniformis is 3:1:1. The beagle heart insufficiency model kit can be used for conveniently and efficiently establishing the beagle heart insufficiency model, and can be applied to clinical medicine research.

Description

technical field [0001] The invention belongs to the field of biological model making, and relates to a kit for establishing a beagle dog model of cardiac insufficiency, which is used for establishing an anthracycline chemotherapeutic drug cardiotoxic animal model. Background technique [0002] Anthracyclines are a kind of cytotoxic anti-tumor anthracyclines. Because of their broad anti-tumor spectrum, strong anti-tumor effect and definite curative effect, they are widely used in the first-line treatment of hematological malignancies and various solid tumors. program, but in contrast, its severe cardiotoxicity limits its further clinical use. In recent years, basic research on doxorubicin-induced cardiotoxicity has revealed some possible molecular mechanisms, such as free radical-induced myocardial oxidative damage, myocardial mitochondrial dysfunction, and the production of drug-iron complexes to aggravate oxidative damage. Autopsy found that anthracyclines can cause vacuol...

AI Technical Summary

Problems solved by technology

[0003] Most of the previously reported animal models were prepared with mice, and the mouse heart is quite different from the human heart, and the heart rate of mice is 8-10 times that of humans, which limits the evaluation of mouse heart function

In addition, the mouse model is administered by intraperitoneal injection of epirubicin in a short period of time and in large doses, which is very different from the clinical dosage and administration method, and the adverse reactions caused by it are also different.

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