Method and kit for establishing beagle heart insufficiency model

A technology of cardiac insufficiency and beagle dogs, applied in the direction of medical formulas, unknown raw materials, medical preparations containing active ingredients, etc., can solve the problems of large heart differences, limitations in the evaluation of mouse heart function, and different adverse reactions and other problems, to achieve the effect of improving the success rate, high success rate, and preventing lower gastrointestinal bleeding

Active Publication Date: 2018-08-31
SHANGHAI HANYU MEDICAL TECH CO LTD
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] Most of the previously reported animal models were prepared with mice, and the mouse heart is quite different from the human heart, and the heart rate of mice is 8-10 times that of humans, which limits the evaluation of mouse heart function
In addition, the mouse model is administered by intraperitoneal injection of epirubicin in a short period of time and in large doses, which is very different from the clinical dosage and administration method, and the adverse reactions caused by it are also different.

Method used

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  • Method and kit for establishing beagle heart insufficiency model
  • Method and kit for establishing beagle heart insufficiency model
  • Method and kit for establishing beagle heart insufficiency model

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Embodiment

[0026] A kit for establishing a beagle dog model of cardiac insufficiency, comprising premixed powder for intravenous infusion, 500 mL of 9% sodium chloride injection, intravenous indwelling needle, infusion set, infusion patch and special container for injection. The premixed powder for intravenous infusion consists of doxorubicin hydrochloride, omeprazole sodium and Bacillus licheniformis (Bacillus Licheniformis, Dutch DSM (DSM) company), containing about 1*10 live bacteria. 11 Colony unit / g), the mass ratio of doxorubicin hydrochloride, omeprazole sodium and Bacillus licheniformis is 3:1:1, doxorubicin hydrochloride and omeprazole sodium are analytically pure, and doxorubicin hydrochloride The total content of Bixing, omeprazole sodium and Bacillus licheniformis is 200mg.

[0027] For use, first weigh and anesthetize 10 adult Beagle dogs. Take the premixed powder for intravenous infusion according to the dose of 2.5 mg / kg according to its body weight, and dissolve it to a ...

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Abstract

The invention provides a method and kit for establishing a beagle heart insufficiency model. The kit is characterized by comprising premixed powder for intravenous drip or injection containing premixed powder for intravenous drip, the premixed powder for intravenous drip is composed of doxorubicin hydrochloride, omeprazole sodium and bacillus licheniformis, the concentration of the premixed powderfor intravenous drip in the injection containing the premixed powder for intravenous drip is 0.4 mg/mL, and the mass ratio of the doxorubicin hydrochloride to the omeprazole sodium to the bacillus licheniformis is 3:1:1. The beagle heart insufficiency model kit can be used for conveniently and efficiently establishing the beagle heart insufficiency model, and can be applied to clinical medicine research.

Description

technical field [0001] The invention belongs to the field of biological model making, and relates to a kit for establishing a beagle dog model of cardiac insufficiency, which is used for establishing an anthracycline chemotherapeutic drug cardiotoxic animal model. Background technique [0002] Anthracyclines are a kind of cytotoxic anti-tumor anthracyclines. Because of their broad anti-tumor spectrum, strong anti-tumor effect and definite curative effect, they are widely used in the first-line treatment of hematological malignancies and various solid tumors. program, but in contrast, its severe cardiotoxicity limits its further clinical use. In recent years, basic research on doxorubicin-induced cardiotoxicity has revealed some possible molecular mechanisms, such as free radical-induced myocardial oxidative damage, myocardial mitochondrial dysfunction, and the production of drug-iron complexes to aggravate oxidative damage. Autopsy found that anthracyclines can cause vacuol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/4439A61K35/742
CPCA61K31/4439A61K31/704A61K35/742
Inventor 程蕾蕾许宇辰赵睿
Owner SHANGHAI HANYU MEDICAL TECH CO LTD
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