Application of orlistat in preparation of drugs for curing constipation

Abstract

The invention belongs to the medicine field and particularly relates to application of orlistat in preparation of drugs for curing constipation. The medicine comprises effective amount of orlistat andeffective amount of konjac glucomannan with different molecular weight, the medicine is formed by certain amount ratio of the konjac glucomannan and the orlistat, it is amazedly found that the medicine has remarkable effect for improving the constipation symptom, at the same time, oil stain and fatty excrement adverse reaction caused by orlistat taking can be effectively relieved, and compared with the prior art, remarkable improvement is obtained.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of lisstat in the preparation of medicaments for treating constipation. Background technique [0002] Orlistat is usually used as a new type of weight loss drug, and it is the only non-central nervous weight loss drug. It is a long-acting and potent specific gastrointestinal lipase inhibitor. The active serine part of lipase and pancreatic lipase combines to form a covalent bond, which inactivates lipase and prevents the decomposition, absorption and utilization of fat in food, so as to achieve the purpose of weight loss. [0003] Although orlistat has a significant effect on weight loss, there are also many adverse reactions that cannot be ignored. Common adverse reactions include oily spots, urgency to defecate, oily spots, increased gastrointestinal exhaust, fatty stool, Increased bowel movements and bowel incontinence. Among them, the adverse reaction of increase...

AI Technical Summary

Problems solved by technology

Due to the high molecular weight, high viscosity and low solubility of natural KGM, its application is greatly limited. At present, natural KGM is mainly degraded by chemical or biological modification methods to obtain different molecular weights and different physical and chemical properties. Konjac glucomannan oligosaccharides (KOGM) with biological functions, and KOGM with different molecular weights have significant differences in physicochemical and biological functions

The combination of konjac glucomannan and orlistat as a drug for treating constipation has not yet been disclosed.

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