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Pharmaceutical composition for treating radiation proctitis

A technology of radiation proctitis and composition, applied in the field of medicine, can solve the problems of inconvenient promotion and use, low level of research on traditional Chinese medicine, etc., and achieve the effect of improving positive fecal occult blood, no toxic and side effects, and reliable curative effect

Inactive Publication Date: 2018-09-14
孔华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research level of traditional Chinese medicine is low, and there is no fixed prescription and special medicine, which is not easy to promote and use

Method used

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  • Pharmaceutical composition for treating radiation proctitis
  • Pharmaceutical composition for treating radiation proctitis
  • Pharmaceutical composition for treating radiation proctitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] The characterization of experimental example 1 medicine of the present invention

[0025]

[0026] 1 H NMR (CDCl 3 ,500MHz)δ1.63(br s,1H),2.33(s,3H),2.37(s,3H),3.02-3.09(m,8H),6.52(m,1H),6.87(m,1H), 7.04(m,1H),7.06-7.10(m,2H),7.16(m,1H),7.39(d,J=7.8Hz,1H); MS(ESI)m / z: 299[MH] + .

experiment example 2

[0027] Experimental example 2 Therapeutic effect of medicine of the present invention for radiation proctitis

[0028] After the rats were acclimated to the environment for 3 days, the weight of each rat was weighed and divided into 5 cages: A (180-187g), B (188-195g), C (196-203g), D (204-211g), E (212~220g), each is given a mark, such as: A1, A2...A12...E12, any number in the random number table is the starting number, according to a certain direction, record the 2 numbers belonging to 1~12, Select the corresponding rats according to the numbers, select one by one in each cage, and finally divide the rats into: blank control group, model group, dexamethasone group, low-dose group of the drug of the present invention, medium-dose group of the drug of the present invention, high-dose drug of the present invention There are 6 groups in total, 10 in each group.

[0029] model preparation

[0030] Reference to the model of literature (Cagatay Korkut, Oktar Asoglu, Murat Aksoy, ...

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Abstract

The invention belongs to the technical field of medicines and in particular relates to a pharmaceutical composition for treating radiation proctitis. The problem in the prior art that an ideal medicine for the radiation proctitis does not exist is solved. The pharmaceutical composition takes a compound comprising the following formula as an effective pharmaceutical ingredient, wherein the structural formula is as shown in the description. In the formula, R1 is independently selected from H, alkyl or halogens; and R2 is independently selected from H, alkyl or -OH. The pharmaceutical compositionfor treating radiation proctitis disclosed by the invention can achieve effects of obviously relieving clinical symptoms such as mucous bloody stool, diarrhea, abdominal pain, anal burning pain and bearing-down pain and the like, improving positive fecal occult blood, colonoscopy mucosa lesions and radiation damage and improving the living quality of patients, is low in recurrence rate, reliablein curative effects, stable in effects and zero in toxic or side effect, and is a satisfactory drug for treating the radiation proctitis.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating radiation proctitis. Background technique [0002] Radiation therapy is an important treatment for abdominal and pelvic malignant tumors. Radiation proctitis is a common complication after radiation therapy for pelvic and abdominal malignant tumors. At present, with the increasing incidence of pelvic and abdominal malignant tumors and the wide application of radiotherapy techniques, the incidence of radiation proctitis is also on the rise. The pathogenesis is mainly that the proliferation of intestinal epithelial cells is inhibited by radiation, and the small arteries of the intestinal submucosal are damaged, causing obliterative arterial endarteritis and venous endarteritis. Pain and inconvenience. [0003] At present, for radiation proctitis, there is still a lack of ideal drugs and treatment methods at home and abroad. ...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61P1/00
CPCA61K31/495
Inventor 孔华
Owner 孔华
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