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A method for manufacturing a film-type cantilever beam surface stress biosensor

A biosensor, surface stress technology, applied in the direction of instruments, measuring force, measuring devices, etc., can solve the problems of reducing test accuracy, complex preparation method, not easy integration and portability, etc., to achieve integration and reduce noise. Affect, overcome the effect of low sensitivity

Active Publication Date: 2020-07-17
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, most of the biosensors based on surface stress are single cantilever beam structures with rigid materials, which have a large Young's modulus, which greatly limits the sensitivity of biosensors
In the existing film-type surface stress biosensor, the gravity of the cantilever beam itself will also deform the cantilever beam during the test process, which will affect the test results and reduce the test accuracy
In addition, the preparation methods of these structures are complex and not easy to integrate and portability

Method used

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  • A method for manufacturing a film-type cantilever beam surface stress biosensor
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  • A method for manufacturing a film-type cantilever beam surface stress biosensor

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Embodiment 1

[0031] A method for manufacturing a film-type cantilever beam surface stress biosensor, comprising the following steps:

[0032] The first step is to use Sylgard 184 and Dow Corning as the raw material base liquid, mix according to the mass ratio of base liquid and curing agent of 10:1, prepare 30mL polydimethylsiloxane stock solution, stir it evenly with a glass rod, and mix the polydimethylsiloxane Put the dimethyl siloxane into a vacuum drying machine to evacuate to remove air bubbles. Pour 10 mL of the polydimethylsiloxane stock solution into a petri dish, and heat the polydimethylsiloxane at 150° C. for 20 minutes with a heating plate to solidify the polydimethylsiloxane to form a substrate with a thickness of about 5 mm. Cut it into a square base of 2cm*2cm with a blade, and then cut a square hole of 1cm*1cm in the central part with a blade. The hole can also be circular or threaded.

[0033] The second step is to prepare a glass sheet of 2cm*2cm as the substrate. After...

Embodiment 2

[0044] A method for manufacturing a film-type cantilever beam surface stress biosensor, comprising the following steps:

[0045] The first step is to use Sylgard 184 and Dow Corning as the raw material base liquid, mix according to the mass ratio of base liquid and curing agent of 10:1, prepare 30mL polydimethylsiloxane stock solution, stir it evenly with a glass rod, and mix the polydimethylsiloxane Put the dimethyl siloxane into a vacuum drying machine to evacuate to remove air bubbles. Pour 10 mL of the polydimethylsiloxane stock solution into a petri dish, and heat the polydimethylsiloxane at 150° C. for 20 minutes on a heating plate to solidify the polydimethylsiloxane to form a substrate with a thickness of 3 mm. It is cut into a square base of 3cm*3cm with a blade, and then a square hole of 1.5cm*1.5cm is cut with a blade at the central part, and the hole can also be circular or spiral.

[0046]The second step is to prepare a glass sheet of 3cm*3cm as the substrate. Af...

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Abstract

The invention relates to the field of manufacturing of biosensors, in particular to a manufacturing method for a thin film type cantilever surface stress biosensor. The manufacturing method comprisesthe following steps: preparing a polydimethylsiloxane substrate from a polydimethylsiloxane stock solution; after heating and curing, cutting a slot in the center of the polydimethylsiloxane substrate; spin-coating a glass substrate with a polydimethylsiloxane thin film, cutting a groove in the center of the polydimethylsiloxane thin film, reducing the polydimethylsiloxane thin film in a chloroauric acid solution, spin-coating the surface of the chloroauric acid thin film with photoresist; adhering the polydimethylsiloxane thin film to the chloroauric acid solution, and cutting into a cross-shaped cantilever to obtain a polydimethylsiloxane thin film substrate; reducing and precipitating nano-gold; stripping the photoresist; and scribing, packing and testing to obtain the final product. Integration and minimization can be realized, and actual application requirements for the biosensor are met.

Description

technical field [0001] The invention discloses a method for manufacturing a film-type cantilever beam surface stress biosensor, which belongs to the technical field of biosensor manufacturing. Background technique [0002] In recent years, biosensors have received widespread attention at home and abroad because of their important applications in disease diagnosis, biosensing materials research, tissue engineering, surface modification, implantable biosensors, and drug release systems. [0003] The biosensor based on surface stress is a new type of biosensor. Due to its advantages of high efficiency, sensitivity, specificity, small structure, economical and practical, it is currently a research hotspot in the field of life sciences and is becoming a powerful general analysis. tool. With the self-development of BioMEMS technology and the further integration of life science and other fields, the development trend and focus of future biosensors are miniaturization, portability,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01L1/22
CPCG01L1/2206
Inventor 张强赵冬桑胜波张益霞禚凯季超杜怡裴臻贾雯丹
Owner TAIYUAN UNIV OF TECH