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Analysis method of easily hydrolyzed ester substances

A technology for easily hydrolyzed substances and analysis methods, which is applied in the direction of analysis of materials, material separation, and measurement devices, and can solve problems such as low sensitivity, inability to measure, and insufficient sensitivity

Inactive Publication Date: 2018-10-09
GUANGDONG RANGER BIOSCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When there is no water, ethyl chloroacetate is usually determined by gas chromatography GC-ECD method, and also by GC-FID method, but the sensitivity is low
However, no matter what gas chromatography method is used, there are problems of large base interference and insufficient sensitivity. If there is water, it cannot be determined.

Method used

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  • Analysis method of easily hydrolyzed ester substances
  • Analysis method of easily hydrolyzed ester substances
  • Analysis method of easily hydrolyzed ester substances

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0056] The analysis process of two different substances, ethyl chloroacetate and dimethyl sulfate, is illustrated as an example.

[0057]1. Choose a non-aqueous solvent that can dissolve the sample to dissolve the sample completely. For example, ethyl chloroacetate is dissolved in ethanol to form a sample solution of ethyl chloroacetate; dimethyl sulfate is dissolved in methanol to form a sample solution of dimethyl sulfate.

[0058] 2. Pipette an appropriate amount of the above sample solution, add an appropriate amount of alcohol that can be produced by the hydrolysis of the ester to be tested, mix well, then slowly add an appropriate amount of concentrated sulfuric acid, stir slowly with a glass rod while adding, cool to room temperature, and then transfer it into a glass bottle ,stand-by.

[0059] The amount of alcohol added is determined by the content of the ester to be tested in the sample, and is generally greater than the amount of alcohol that can be generated by hy...

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Abstract

The invention discloses an analysis method of easily hydrolyzed ester substances. The analysis method of the easily hydrolyzed ester substances comprises the following steps: taking a sample containing ester substances to be tested, wherein the ester substances are the easily hydrolyzed ester substances; adding alcohol, which can be produced after hydrolysis of the easily hydrolyzable substances,into the sample; adding a substance capable of binding water into the sample so as to convert free water into bound water; injecting the sample into a chromatographic apparatus for detection by usingheadspace sampling. The analysis method of the easily hydrolyzed ester substances can prevent the hydrolysis of the ester substances and the interference of substrate, and can accurately determine thecontent of the ester substances.

Description

technical field [0001] The invention relates to the technical field of chromatographic analysis, in particular to an analysis method for easily hydrolyzed ester substances. Background technique [0002] Esters, as spices, condiments or impurities, are ubiquitous in food, drug, beverage and beverage products, and some of them, such as methyl chloroformate, ethyl chloroformate, dimethyl sulfate, diethyl sulfate, etc., have been proven to have Genotoxicity is a component that needs to be closely monitored in pharmaceuticals and food and beverages. Therefore, the simple and quick determination of volatile esters is very important for the fields of biopharmaceuticals and food safety. Due to the volatile nature of these esters, gas chromatography is naturally the best technique for their analysis. However, many volatile ester compounds are easy to decompose when exposed to water, such as sulfuric acid esters, phosphate esters, halogenated esters, etc. Even if the sample contains ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 张军朱建雄
Owner GUANGDONG RANGER BIOSCI CO LTD
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