Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Stem cell preparation sponge patch complex for treating cerebral diseases as well as preparation method and application thereof

A stem cell preparation and complex technology, applied in the field of biomedicine and tissue engineering research, can solve the problems of restricting the absorption and efficacy of stem cell preparations, uneven distribution, and nasal loss, so as to promote absorption and efficacy, and reduce pain. Effect

Inactive Publication Date: 2018-10-16
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also some problems in the intranasal transplantation approach. The nasal mucosa has a mucociliary clearance system, which makes the existing nasal administration dosage forms, including nasal drops and gels, unevenly distributed in the nasal cavity, and is easy to be lost from the nasal cavity. Limit the absorption and efficacy of stem cell preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stem cell preparation sponge patch complex for treating cerebral diseases as well as preparation method and application thereof
  • Stem cell preparation sponge patch complex for treating cerebral diseases as well as preparation method and application thereof
  • Stem cell preparation sponge patch complex for treating cerebral diseases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation and investigation of stem cell preparation sponge patch complex.

[0036] 1 Preparation and performance investigation of neural stem cell preparation

[0037] 1.1 Collection and transportation of neural stem cell tissue source

[0038] 1) The source of the tissue is aborted fetus (medical waste) at 8-14 weeks of gestation, and the informed consent form "Collection and Preservation of Donor Tissue Samples" should be signed.

[0039] 2) Collect the relevant medical staff to select the container according to the size of the tissue, put it into a sterile tube, seal the tube opening with a parafilm, wipe and disinfect the surface of the tube with alcohol, and put it into the transport box.

[0040] 3) During transportation, the vehicle should be kept stable to avoid impact on the box. The interior of the transport vehicle should be clean, and the temperature inside the vehicle should be controlled below 20°C, and the temperature in the transport box should be a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
porosityaaaaaaaaaa
porosityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a stem cell preparation sponge patch complex for treating cerebral diseases as well as a preparation method and application thereof. The complex is degradable sponge wetted bystem cell suspension, and the stem cells fill pores of a network structure of a sponge material in a suspension state. The complex plays a role of rigid proppant, can be clamped by machines, and can be directly sent to a cell treatment physical site without invasion; the complex also has the deformation capability, can be clamped at the treatment site to release the cell so as to better promote the absorption of the stem cell preparation and the playing of the drug effect; the complex is compounded in an embedded loosening way, and the stem cells can be loaded and carried by a material and canbe freely released under the effect of an external force; the sponge material of the complex only plays a role in loading the stem cells and carrying the stem cells to the treatment site and then isbiologically degraded, so that the residue of foreign matters can be effectively avoided; and the biological compatibility is good. The stem cell preparation sponge patch complex is suitable for noninvasive and individual nasal cavity application and is used for treating the cerebral diseases.

Description

technical field [0001] The invention belongs to the field of biomedicine and tissue engineering research, and specifically relates to a preparation method and application of a stem cell preparation sponge patch complex for treating brain diseases. Background technique [0002] Brain diseases refer to brain nerve tissue damage caused by genetics, congenital brain hypoplasia, brain trauma, brain tumors, cerebral hemorrhage, cerebral infarction, infection, chemical drug poisoning, etc., covering brain organs with abnormal tissue structure and physiological functions qualitative damage. According to the cause of the disease, brain diseases are divided into three categories: ①Children with cerebral palsy and mental retardation caused by heredity and congenital dysplasia; Nerve damage leads to chronic degenerative diseases caused by aging and degeneration of brain nerve cells, including Alzheimer's disease, brain atrophy, Parkinson's disease, etc. There are about 10 million new ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/42A61K35/30A61P25/00
CPCA61K47/42A61P25/00A61K9/0043A61K9/0087A61K35/30A61L27/222A61L27/56A61L27/58A61L27/3834A61L27/3878A61K9/0024
Inventor 刘晶马静云韩朝
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com