Supercharge Your Innovation With Domain-Expert AI Agents!

A kind of tea saponin cerium complex, tea saponin cerium nanoparticle and its preparation method and application

A nanoparticle and tea saponin technology, which is applied in the field of tea saponin, can solve the problems of tea saponin, such as large molecular weight, difficult absorption, and poor stability, and achieve the effects of easy absorption, enhanced biological activity, and mild reaction conditions

Inactive Publication Date: 2020-12-22
SOUTH CHINA UNIV OF TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight of tea saponin is large, it is not easy to absorb, and it is easy to degrade in the body and has poor stability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of tea saponin cerium complex, tea saponin cerium nanoparticle and its preparation method and application
  • A kind of tea saponin cerium complex, tea saponin cerium nanoparticle and its preparation method and application
  • A kind of tea saponin cerium complex, tea saponin cerium nanoparticle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Take 1kg of tea saponin and add 15kg of water to dissolve it, then add 1000U of α-glucosidase, keep it at 65°C for 4 hours; let it stand for stratification, and collect the precipitate;

[0033] (2) Take 100g of the precipitate and dissolve it with 1L volume fraction of 70% ethanol solution, add 10g of cerium nitrate ethanol solution and 1g of polyethyleneimine (molecular weight 10000Da, n≈20) with a mass fraction of 5% Adjust the pH value to 6 with sodium hydroxide, and react at 55°C for 5 hours;

[0034] (3) Concentrate under reduced pressure at 0.01MPa at 50°C for 3h to evaporate ethanol, pass through a 0.22μm filter membrane, and dry in vacuum at 60°C for 8h to obtain 105g of tea saponin cerium nanoparticles.

Embodiment 2

[0036] (1) Take 1kg of tea saponin and add 30kg of water to dissolve it, then add 10000U of α-glucosidase, keep it warm at 35°C for 12h; let it stand for stratification, and collect the precipitate;

[0037] (2) Take 100g of the precipitate and dissolve it with 2L volume fraction of 85% ethanol aqueous solution, add 20g of 30% cerium nitrate ethanol solution and 5g of polyethyleneimine (molecular weight 500Da, n≈1), and use 20% of mass fraction Adjust the pH value to 7 with sodium hydroxide, and react at 65°C for 2 hours;

[0038] (3) Concentrate under reduced pressure at 0.1MPa at 70°C for 3h to distill off ethanol, pass through a 0.45μm filter membrane, and dry in vacuum at 50°C for 9h to obtain 110g of tea saponin cerium nanoparticles.

Embodiment 3

[0040] (1) Take 1kg of tea saponin and add 20kg of water to dissolve it, then add 5000U of α-glucosidase, keep it at 45°C for 8h; let it stand for stratification, and collect the precipitate;

[0041] (2) Take 100g of the precipitate and dissolve it with 1.5L volume fraction of 75% ethanol aqueous solution, add 15g of 40% mass fraction of cerium nitrate ethanol solution and 3g of polyethyleneimine (molecular weight 1000Da, n≈2), and use a mass fraction of 10% sodium hydroxide to adjust the pH value to 6.5, and react at 60°C for 3h;

[0042] (3) Concentrate under reduced pressure at 0.02MPa at 60°C for 2h to evaporate ethanol, pass through a 0.3μm filter membrane, and dry in vacuum at 50°C for 8h to obtain 108g of tea saponin cerium nanoparticles.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention discloses a tea saponin cerium compound. The tea saponin cerium compound is composed of one molecule of tea saponin, one molecule of a cerium atom and one molecule of polyethyleneimine.The invention further discloses a preparation method of tea saponin cerium nanoparticles containing the tea saponin cerium compound; the preparation method comprises the following steps: (1) adding water into the tea saponin and dissolving; then adding alpha-glucosidase and carrying out heat insulation at 35 to 65 DEG C for 4 to 12 h; standing and layering, and collecting sediment; (2) dissolvingthe sediment with an ethanol water solution; adding a cerium nitrate ethanol water solution which is 10 to 20 percent of the mass of the sediment, and the polyethyleneimine which is 1 to 5 percent ofthe mass of the sediment; regulating the pH (Potential of Hydrogen) value to 6 to 7; reacting at 55 to 65 DEG C for 2 to 5 h; (3) decompressing and concentrating to evaporate ethanol; enabling a product to pass through a filtering membrane with the size of 0.22 to 0.45 mum, and drying in vacuum to obtain the tea saponin cerium nanoparticles. The invention further discloses the tea saponin cerium nanoparticles and application thereof. The tea saponin cerium compound disclosed by the invention can be used for effectively reducing the biological toxicity of inorganic cerium and a cooperative effect of tea saponin and the cerium is expressed to improve the anti-tumor effect; the tea saponin cerium compound is simple to prepare and can be used for preparing a gastrointestinal tumor resisting medicine.

Description

technical field [0001] The invention relates to tea saponin, in particular to a tea saponin cerium complex, tea saponin cerium nanoparticles and a preparation method and application thereof. Background technique [0002] Gastrointestinal cancer is the most common and most important malignant tumor, including gastric cancer, colon and rectal cancer, etc. Commonly used chemotherapeutic drugs have toxicity such as bone marrow suppression, hair loss, and liver and kidney damage. Traditional Chinese medicines or other biological drugs have low toxicity, but slow onset, poor effect, and high prices. [0003] Tea saponin is a pentacyclic triterpenoid compound extracted from the waste tea dregs after tea seed oil extraction, and its price is low. Tea saponin has antitumor effect. However, the molecular weight of tea saponin is large, it is not easy to absorb, and it is easy to degrade in the body, and its stability is poor. [0004] Cerium is the most abundant light rare earth me...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00C08G73/04A61P35/00
CPCA61P35/00C07J63/008C08G73/0206C08G73/0213
Inventor 张靖瑶叶勇
Owner SOUTH CHINA UNIV OF TECH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com