Synthetic method of p-(2-methoxyethyl) phenol
A technology of methoxyethylphenol and synthesis method, which is applied in chemical instruments and methods, preparation of ether from alkylene oxide, preparation of organic compounds, etc., can solve the problem of large amount of "three wastes" and low yield of methoxyethylphenol and other problems, to achieve the effect of high product purity, reduced post-processing difficulty and good product stability
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Embodiment 1
[0026] Add 200g of p-chlorophenol, 429.6g of potassium carbonate, and 378g of DMF to a 1000mL three-necked flask, stir and raise the temperature to 80°C, stir for 1h, add 208g of benzyl chloride dropwise (dropping time is about 0.5h); react at 105°C for 1h, cool to 80°C, Filter, distill off DMF under reduced pressure, and cool to room temperature to obtain 327.5 g of p-benzyloxychlorobenzene with a yield of 96.31%. Purity 98.4% (HPLC).
Embodiment 2
[0028] Other conditions are with embodiment 1, check the experiment of different benzyl chloride, salt of wormwood consumption, experimental result is shown in Table 1.
[0029] Table 1 reaction varies with the amount of benzyl chloride
[0030]
Embodiment 3
[0032] Add 14.82g of magnesium powder and 189g of methyl tetrahydrofuran into a three-necked flask, heat to reflux, add dropwise a solution of methyl tetrahydrofuran in which 122g of p-benzyloxychlorobenzene is dissolved, add 1-2 grains of iodine to trigger, and reflux for 2 hours after the dropwise addition. The temperature was lowered to 0°C, and 49.41 g of ethylene oxide was added dropwise. After the reaction, pour it into water, separate methyl tetrahydrofuran, concentrate and crystallize to obtain 98.5 g of p-benzyloxyphenethyl alcohol, with a purity of ≥95% (HPLC).
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