16results about How to "Reduce post-processing difficulty" patented technology

The invention relates to the technical field of fine chemical synthesis, and discloses a high-conversion-rate preparation method of 2-(2 '-hydroxy-3'-methallyl-5 '-methylphenyl) benzotriazole, which comprises the following steps: mixing 2-(5-methyl-2-((2-methallyloxy) phenyl)-2H-benzo [1, 2, 3] triazole with a solvent, carrying out rearrangement reaction, cooling, crystallizing, washing and drying to obtain 2-(2'-hydroxy-3 '-methallyl-5'-methylphenyl) benzotriazole. The 2-(2 '-hydroxyl-3'-methallyl-5 '-methylphenyl) benzotriazole is prepared through a one-pot method; the solvent is selected from N, N-dialkylaniline compounds or N, N-dialkylaniline compounds with alkyl substituted on a benzene ring. By screening and replacing the Claisen rearrangement solvent, the reaction time is effectively shortened, the reaction conversion rate is greatly improved, the side reaction is remarkably inhibited, the post-treatment difficulty is reduced, and the material and production cost is greatly reduced.

The application relates to the field of catalysts, and discloses a hydroisomerization catalyst, a preparation method thereof and a hydroisomerization treatment method for hydrocarbon oil, which comprises the following steps: (1) performing molding on a ZSM-48 molecular sieve precursor to obtain a carrier precursor; wherein the water content of the ZSM-48 molecular sieve precursor is not less than 15 wt% based on the mass of the ZSM-48 molecular sieve precursor; (2) performing ammonium exchange on the carrier precursor to obtain a catalyst carrier; (3) introducing an active metal component onto the catalyst carrier to obtain a hydroisomerization catalyst; wherein the active metal component is Pt and / or Pd. The hydroisomerization catalyst obtained by the above preparation method has a lower product condensation point and a higher yield in the hydroisomerization reaction of hydrocarbon oil than the product obtained by the prior art, and has a remarkable effect.

The invention relates to the technical field of fine chemical engineering, in particular to the field of IPC C07C303, and more particularly relates to alicyclic ethoxylated sodium bisphenol sulfonate and a preparation method thereof. A structural general formula is shown as a formula 1: # imgabs0 #, wherein X comprises one of O, CH2 and (CH3) 2C, and R comprises an unsaturated ring. The preparation method comprises the following steps: S1, etherification reaction: adding cycloolefin, an ethoxylated bisphenol compound and an acidic catalyst into a reaction solvent, heating for reaction, and removing the solvent, the catalyst and excessive cycloolefin to obtain an alicyclic ethoxylated bisphenol intermediate; and S2, sulfonation and neutralization reaction: cooling the intermediate, dropwise adding a sulfonation reagent for reaction, and performing post-treatment to obtain the product. The preparation method is simple and mild, and has good water solubility and surface activity.

This invention provides a method for preparing 1,2-propanediol and its application. The method includes: step (1): in the presence of an acidic catalyst and water, ring-opening of a first portion of propylene oxide to obtain an acid-catalyzed reaction solution containing 1,2-propanediol; step (2): in the presence of an alkaline catalyst and water, ring-opening of a second portion of propylene oxide to obtain an alkaline-catalyzed reaction solution containing 1,2-propanediol; step (3): mixing the obtained acid-catalyzed reaction solution and the alkaline-catalyzed reaction solution for a neutralization reaction to obtain a mixture containing 1,2-propanediol; wherein, the molar ratio of the first portion of propylene oxide to water in step (1) and the molar ratio of the second portion of propylene oxide to water in step (1) are each independently 1:1-5; using the method of this invention to prepare 1,2-propanediol requires only a lower water ratio to obtain a higher propylene oxide conversion rate and 1,2-propanediol content, and the wastewater volume is lower and the color is colorless after the reaction.

The invention provides preparation of a nitrogen-doped carbon-loaded bimetallic catalyst and a method for constructing a 3-thioindole compound with a C-S bond by catalyzing S-C aerobic oxidation through the nitrogen-doped carbon-loaded bimetallic catalyst, and belongs to the technical field of chemical engineering. The nitrogen-doped carbon-loaded bimetallic catalyst is prepared through pyrolysis, the catalyst is of a mesoporous structure, the nitrogen-doped carbon-loaded bimetallic catalyst serves as the catalyst, a sulfhydryl compound and an indole compound are heated and stirred in a solvent in an oxygen-containing environment, the 3-thioindole compound with an S-C bond is generated, the preparation method of the catalyst is simple, the catalytic activity is excellent, and the catalyst can be used for preparing the 3-thioindole compound with the S-C bond. The reaction efficiency is high, the product selectivity is high, the catalyst can be repeatedly used, and the industrial application prospect is relatively strong.

The invention discloses application of basophilic bacillus and a microbial agent thereof in production of standard natural rubber 10 # rubber by taking skim gum as a raw material, and belongs to the field of primary processing of natural rubber. According to the invention, the bacillus alcalophilus CICC 23037 and the microbial inoculum thereof are used for producing standard natural rubber No. 10 rubber by taking skim gum as a raw material; the bacillus alcaliphilus CICC 23037 grows well in the skim skim with high ammonia content, continuously secretes protease to remove rubber protein in the skim skim, simultaneously secretes organic acid, neutralizes ammonia in the skim skim, reduces the pH value of the skim skim and destroys the stability of latex, so that the skim skim is solidified in a range that the pH value is less than or equal to 9.0; the technical indexes of the skim rubber obtained by the method provided by the invention meet the performance requirements of No. 10 rubber in GB / T 8081-2018 natural raw rubber technology graded rubber (TSR) specification guide rule.

The invention relates to the technical field of iso-butane normalizing, and discloses an iso-butane normalizing method and an iso-butane normalizing reaction system.The iso-butane normalizing method comprises the step that under the hydrogen condition and the iso-butane normalizing reaction condition, an iso-butane raw material makes contact with a catalyst, wherein the catalyst comprises an acidic active component SO4 < 2-> / ZrO2, an all-silicon molecular sieve with an MFI structure and aluminum oxide; the density of the strong acid center in the catalyst is 0.1-2 [mu] mol / m < 2 >. The method has the advantages of high isobutane conversion per pass, high n-butane selectivity and high n-butane yield.

The utility model discloses a stirring, desanding and decontaminating device for anaerobic fermentation of livestock and poultry manure, which relates to the technical field of stirring, desanding and decontaminating devices, and comprises a box body, a box door is rotatably arranged at an opening on the upper side surface of the box body, a feeding cylinder is arranged at the opening on the upper surface of the box body, and a discharge port is arranged at the opening on the lower surface of the box body. A discharging opening is formed in the upper surface of the box body, an electric valve is arranged on the discharging opening, four supporting legs are symmetrically arranged on the lower surface of the box body, supporting feet are fixedly arranged on the lower surfaces of the supporting legs, drainage plates are symmetrically arranged at the bottom of the inner wall of the box body, a filter screen plate is arranged above the drainage plates, and a stirring assembly is arranged above the filter screen plate; a filtering assembly is arranged at the top of the inner side of the box body, and a collecting assembly is arranged on the side face of the feeding barrel. Through the cooperation of the stirring assembly, the filtering assembly and the collecting assembly, the purposes of controlling and treating exhaust gas and avoiding the influence on the health of workers are achieved, and the influence of excrement on the service life of the device is prevented.

The invention provides a continuous purification method of a pyroxasulfone intermediate, which comprises the following steps: a synthesized mixed solution containing 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole of the pyroxasulfone intermediate enters a continuous extraction liquid separation device, the mixed solution is subjected to extraction separation to obtain an organic phase and a water phase, and the lower organic phase is extracted to a buffer tank; pumping the organic phase in the buffer tank into the middle section of a continuous distillation device, keeping the continuous distillation device at negative pressure, and obtaining a primary purified product at the bottom of the continuous distillation device; and pumping the primary purified product into the middle part of a continuous rectification device, and keeping the continuous rectification device at negative pressure, wherein the liquid extracted by a first-stage condenser is the pyroxasulfone intermediate. The reaction liquid is kept to be distilled, rectified and condensed at a specific temperature during post-treatment, so that the influence of high-temperature fractions (component 2) on the subsequent oxidation reaction is effectively removed, and the purity and yield of the final product pyroxasulfone are improved. And a high-purity product (the GC purity is 99% or above) is obtained, and the method has great significance in a full-continuous process.

The application discloses a method for recovering chiral phosphoric acid from bedaquiline waste liquid, and belongs to the technical field of waste liquid recovery, and comprises the following steps: (1) separating enantiomers and chiral phosphoric acid salt: recovering bedaquiline split mother liquor under reduced pressure, and obtaining organic phase containing enantiomers and water phase containing chiral phosphoric acid salt after liquid separation; (2) recovering enantiomers: recovering the organic phase in step (1) under reduced pressure, crystallizing, filtering and drying to obtain enantiomers; (3) freeing chiral phosphoric acid: combining the water phase obtained in step (1) with the water phase generated in the bedaquiline freeing process, adjusting the pH to be acidic, adding diatomite for adsorption, filtering to obtain filter cake; (4) recovering chiral phosphoric acid: adding tetrahydrofuran and water into the filter cake, stirring and dispersing, crystallizing, filtering, drying and obtaining chiral phosphoric acid. The application can effectively recover chiral phosphoric acid contained in bedaquiline waste liquid, greatly reduces production cost, and has higher economic benefits.

The invention discloses a synthesis method of a beta-aryl ethyl amine medicine, and belongs to the technical field of medicinal chemistry. The synthesis method comprises the following steps: S1, carrying out a reaction I on a mixed raw material containing a secondary amine compound and a nitrosation reaction solvent to obtain a nitrosamine compound; s2, a mixture containing a nitrosamine compound, aryl iodide, an oxidizing agent, a catalyst and a solvent is subjected to a reaction II, and an aryl ethyl amine prodrug is obtained; and S3, removing a nitroso group from the aryl ethyl amine drug precursor, so as to obtain the beta-aryl ethyl amine drug. The synthesis method takes simple and easily available initial raw materials as the starting end of a synthesis route, avoids the use of excessive metal compounds as oxidizing agents, reduces the synthesis cost and post-treatment difficulty, can be used for large-scale test, has high product purity, and is suitable for industrial production. The novel method for synthesizing the beta-aryl ethyl amine medicine, which is easy to operate, good in atom economy, high in selectivity, environment-friendly and novel, is realized.

The present invention provides a diazatricyclic amine compound, a preparation method and an application thereof, and belongs to the field of tricyclic amine compounds. The diazatricyclic amine compound has a structure as shown in the following formula: #imgabs0#; wherein R is an alkyl group containing 1-6 carbon atoms, or R is M-(CH2) m R 1 ; M is CHJ or G, J is H or an alkyl group of 1-6 carbon atoms, and G is selected from a fully saturated or partially saturated cycloalkyl group; R 1 C(=NR 2 )NH、NHC(=NR 3 )NH2 or NR 4 R 5 ; said R 2 , R 3 , R 4 , R 5 are all independent alkyl groups with 1-4 carbon atoms, and m is an integer of 0-4. The results of biological activity tests on the diazatricyclic amine compounds of the present invention show that the compounds have an inhibitory effect on colon cancer cells.

The present invention provides a diazatricyclic amine compound, a preparation method and an application thereof, and belongs to the field of tricyclic amine compounds. The diazatricyclic amine compound has a structure as shown in the following formula: #imgabs0#; wherein R is an alkyl group containing 1-6 carbon atoms, or R is M-(CH2) m R 1 ; M is CHJ or G, J is H or an alkyl group of 1-6 carbon atoms, and G is selected from a fully saturated or partially saturated cycloalkyl group; R 1 C(=NR 2 )NH、NHC(=NR 3 )NH2 or NR 4 R 5 ; said R 2 , R 3 , R 4 , R 5 are all independent alkyl groups with 1-4 carbon atoms, and m is an integer of 0-4. The results of biological activity tests on the diazatricyclic amine compound of the present invention show that the compound has an inhibitory effect on colon cancer cells.

The invention belongs to the technical field of steroid medicine preparation, and particularly relates to a preparation method of fluticasone furoate. By directly increasing the dosage of the furfuryl chloride, the intermediate, namely the compound A with higher activity than that of a traditional intermediate is synthesized, an additional coupling agent and a coupling enhancer do not need to be introduced, impurities, especially dimer impurities, caused by a coupling reaction are avoided, the cost is greatly saved, and the post-treatment difficulty is reduced; the diesterified compound A synthesized by the invention cannot be subjected to intramolecular polymerization, does not use additional special reagents, does not introduce additional side reactions and impurities, reduces the refining process, and reduces the post-treatment difficulty; a one-pot method is adopted, so that the risk of side reaction caused by discharging is avoided. In conclusion, compared with a traditional process, the preparation method provided by the invention reduces generation of impurities and has the advantages of high weight yield and high purity, the purity is 99% or above, and the weight yield is 120% or above.

The invention discloses a naphthalene ring derivative, a synthesis method and application, and provides a series of novel naphthalene ring derivatives substituted by different functional groups. Compared with the existing naphthalene ring derivative, the naphthalene ring derivative provided by the invention is a functional group substituted naphthalene ring, and is easily subjected to subsequent chemical conversion and further converted into a high-added-value compound. According to the efficient synthesis method of the naphthalene ring derivative, the substrate applicability is wide, raw materials are cheap, synthesis is easy, high temperature and use of a catalyst are not needed in the reaction process, and various substituent-substituted naphthalene ring compounds can be prepared. The reaction process is milder, the safety is high, the post-treatment difficulty is reduced, high temperature and high pressure are not needed, only visible light irradiation is needed, meanwhile, the use of expensive metal catalysts and organic photocatalysts is avoided, and the post-treatment difficulty is reduced. The method also has the advantages of simple operation, simple steps, high yield, large-scale synthesis and the like.

The utility model relates to the technical field of sewage treatment, and discloses a sewage treatment moving device which comprises a moving transport case and a primary filter cartridge, a filter plate is detachably connected to an inner cavity of the primary filter cartridge, a second transmission rod is vertically and rotatably connected to the center of the filter plate, and a cleaning scraper is arranged on the lower surface of the filter plate. The tail end of the cleaning scraper is fixedly connected to the surface of the second transmission rod, a servo motor is connected to the top end of the primary filter cylinder in an embedded mode, and the power output end of the servo motor is detachably connected with the top end of the second transmission rod. According to the sewage treatment device, sewage can be effectively primarily filtered by virtue of the primary filter cylinder when the sewage treatment device moves, and a sewage treatment agent can be automatically fed in cooperation with the feeding structure in the primary filtering process and is synchronously stirred, so that the sewage treatment can be carried out in the transportation process, the sewage treatment time is effectively shortened, and the sewage treatment efficiency is further improved.