The invention discloses a feed additive for treating self-biting disease of minks and a preparation method thereof. The feed additive is prepared from the following ingredients: acanthopanax root, mothers of pearl, dens draconis, goat horns, Ludisia discolor, radix paeoniae rubra, cynanchum atratum, spina gleditsiae, eucalyptus leaves, citrus aurantium, red roses, flowers of silktree albizzia, Cortex Sophorae, radix astragali, red halloysite, honey, pine needle meal, shrimp meal, rice bran, silkworm chrysalis, fish scale and olive oil. The feed additive disclosed by the invention can be used for effectively treating canine distemper of the minks and is low in drug residue, good in treatment effect, high in cure rate and low in toxic or side effects, the cure recovery period is shortened, the food intake of the minks is increased, the use is convenient, and the economic benefit of farmers is increased.