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Preparation method of amino-substituted hydrocarbyl sulfonic acid

A technology of hydrocarbyl sulfonic acid and amino group, which is applied in the field of preparation of amino-substituted hydrocarbyl sulfonic acid, can solve problems such as not reaching an ideal state, and achieve the effects of improving production environment, short reaction time and simple operation.

Inactive Publication Date: 2010-06-30
CHANGSHU 3F ZHENFU NEW MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] In summary, the current preparation method of amino-substituted hydrocarbyl sulfonic acid still has not reached the best ideal state, so there is an urgent need for a simpler, more economical, improved product quality, safe and pollution-free production method

Method used

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  • Preparation method of amino-substituted hydrocarbyl sulfonic acid
  • Preparation method of amino-substituted hydrocarbyl sulfonic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0027] In a 1L autoclave with magnetic stirring, heating, and pressurization system, add 200g (1.52mol) of sodium sulfite with a content of 96% and 205g (1.38mol) of amino alcohol sulfate with a content of 95%, and then fill it with water, seal it, and magnetically Stir. Increase the pressure in the kettle to about 5Mpa by adding water pressure through a high-pressure pump, and quickly heat it to about 180°C. After reacting for 2 hours, stop stirring, concentrate while it is hot, remove Glauber's salt, cool the mother liquor to 32°C to crystallize, and filter to obtain Taurine crude product 142g.

[0028] Put 142g of the above-mentioned crude taurine into a 500ml four-necked reaction flask, add 220ml of pure water, heat to 85°C to completely dissolve the crude taurine, add 0.6g of activated carbon, stir for half an hour, remove the activated carbon by filtration, and cool down Crystallize at 8°C. After separation by filtration, washing and drying, 114 g (0.91 mol) of taurine...

Embodiment 2

[0030] In a 1L autoclave with magnetic stirring, heating, and pressurization system, add 335 g (2.42 mol) of ammonium sulfite with a content of 84% and 300 g (2.02 mol) of amino alcohol sulfate with a content of 95%, and then fill up with water , sealed, and magnetically stirred. Increase the pressure in the kettle to about 8Mpa by adding water pressure through a high-pressure pump, and quickly heat it to about 220°C. After reacting for 0.5 hours, stop stirring, concentrate part of the water while it is hot, cool down to 5°C to crystallize, and obtain taurine after filtration. Crude product 203.6g.

[0031] Put the crude taurine above into a 1000ml four-necked reaction flask, add 400ml of pure water, heat to 85°C to completely dissolve the crude taurine, add 1g of activated carbon, stir for half an hour, remove the activated carbon by filtration, and cool down to 85°C. ℃ crystallization. After separation by filtration, washing and drying, 179 g (1.43 mol) of taurine refined ...

Embodiment 3

[0033] In the autoclave of 1L band magnetic stirring, heating, pressurization system, add content and be that 96% sodium sulfite 169g (1.29mol) and content are 200g (1.21mol) of 94% 3-amino propanol sulfate and be full of water again, Seal and stir magnetically. Increase the pressure in the kettle to about 5Mpa by adding water pressure through a high-pressure pump, and quickly heat it to about 180°C. After reacting for 2 hours, stop stirring, concentrate while it is hot, remove Glauber's salt, cool the mother liquor to 32°C to crystallize, and filter to obtain The crude product of aminopropanesulfonic acid was 139g.

[0034] Put 139g of the crude product of aminopropanesulfonic acid into a 500ml four-necked reaction flask, add 200ml of pure water, heat to 85°C to completely dissolve the crude aminopropanesulfonic acid, add 0.55g of activated carbon, stir for half an hour, and filter to remove the activated carbon , cooled to 8°C for crystallization. After separation by filtr...

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Abstract

The invention provides a preparation method of amino-substituted hydrocarbyl sulfonic acid, which is characterized by comprising the following steps of: carrying out substitution reaction by taking esters of amino-substituted hydrocarbyl alcohol as raw materials and sulphite as a nucleophilic substitution reagent at high temperature and high pressure, concentrating and separating for desalination after reaction so that a coarse product of the amino-substituted hydrocarbyl sulfonic acid is obtained, and then purifying and crystallizing the coarse product so that the finished product of the amino-substituted hydrocarbyl sulfonic acid is obtained. The preparation method of the amino-substituted hydrocarbyl sulfonic acid is used for carrying out the substitution reaction at high temperature and high pressure by using the esters of the amino-substituted hydrocarbyl alcohol as raw materials and the sulphite as the nucleophilic substitution reagent so as to have the advantages of short reaction time and energy saving; the preparation method also has the advantage of less side reaction, simple postprocessing operation, high yield and favorable quality of the finished product; and the preparation method has no generation of SO2 gas in the production process so as to greatly improve the production environment and have safety.

Description

technical field [0001] The invention relates to a chemical production technology, in particular to a preparation method of amino-substituted hydrocarbyl sulfonic acid. Background technique [0002] Amino-substituted alkyl sulfonic acid is a commonly used food nutrition enhancer, health care product, pharmaceutical raw material and organic synthesis intermediate. [0003] The industrial production method of reported amino-substituted hydrocarbyl sulfonic acid mainly contains following several kinds at present, enumerates as follows: [0004] 1. Oxidation of 2-mercaptoethylamine or 3-mercaptopropylamine to obtain (2-aminoethanesulfonic acid) (3-aminopropanesulfonic acid) respectively. [0005] [0006] The method is to pass oxygen into 2-mercaptoethylamine or 3-mercaptopropylamine, and obtain 2-aminoethanesulfonic acid or 3-aminopropanesulfonic acid through catalytic oxidation, and the yield can reach about 85%, but the raw material mercaptoethylamine Amines and mercaptop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/14C07C303/02
Inventor 贺辙刘遗松朱文杰邵学青严志杰顾仁华钱继新赵婷
Owner CHANGSHU 3F ZHENFU NEW MATERIALS CO LTD
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