Rhizoma bletillae extract and application thereof

A technology of extract and ethanol extract, which is applied in the field of white and extract and its application, can solve the problems of unstable preparation quality and unknown medicinal ingredients

Inactive Publication Date: 2018-11-06
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide an extract of Radix Radix Radix and its application, which solves the problems of unknown active ingredients of the existing traditional Chinese medicine Radix Radix Radix

Method used

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  • Rhizoma bletillae extract and application thereof
  • Rhizoma bletillae extract and application thereof
  • Rhizoma bletillae extract and application thereof

Examples

Experimental program
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Embodiment 1

[0025] Embodiment 1 white and extract

[0026] 1. Preparation of white and extract:

[0027] 1) Slicing, drying and powdering of Baiji tubers, passing through a 50-mesh sieve, weighing 500 g of Baiji dry powder, refluxing and extracting with 3.5 L of 80% ethanol aqueous solution with a volume concentration of 3.5 L, filtering, collecting the filtrate, repeating the extraction 3 times in total, and combining the filtrates, That is white and ethanol extract (dried, denoted as E total);

[0028] 2) Add 100g of 60-100 mesh polyamide (Zhejiang Luqiao Sijia Biochemical Plastic Factory, Taizhou City, Zhejiang Province, batch number 2015617) and 500mL of distilled water to the filtrate of step 1), mix well, and steam under reduced pressure until there is no alcohol smell, and obtain adsorption white and Polyamide suspension of alcohol extract;

[0029] 3) Add 20g of 60-100 mesh polyamide dry powder suspended in 200mL of distilled water to a chromatography column with a diameter of 5...

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Abstract

The invention discloses a rhizoma bletillae extract and application thereof. The rhizoma bletillae extract is prepared by the following steps: carrying out backflow extraction on dried rhizoma bletillae powder with a 60-90% ethanol solution, filtering, and collecting filtrate so as to obtain a rhizoma bletillae alcohol extract; adsorbing the rhizoma bletillae extract with polyamide and a D101 macroporous resin in sequence, collecting a 35-45% ethanol eluant, and carrying out vacuum evaporation drying, thereby obtaining the rhizoma bletillae extract. In-vivo SD (Sprague Dawley) rat chronic bronchitis mode experiments show that rhizoma bletillae and an effective part EFB have a treatment function on chronic bronchitis by inhibiting inflammatory factors such as TNF-alpha, IL-1 beta and IL-6,and by increasing oxidation stress levels.

Description

(1) Technical field [0001] The present invention relates to a kind of white root extract and its application. (2) Background technology [0002] Baiji is the dry tuber of orchid plant white and Bletilla striata (Thunb.) Reiehb.f., which has the effects of astringent and hemostasis, swelling and granulation, and is used for hemoptysis, hematemesis, traumatic bleeding, sore swelling, chapped skin, etc. disease. "Compendium of Materia Medica" states that it "can enter the lungs to stop bleeding, promote muscle regeneration and treat sores." It also has magical effects"; "Yifang Jijie" clearly records: white and ground powder, mixed with rice drink, can cure cough, lung impotence, hemoptysis and red phlegm. It can be seen that the curative effect of Baiji on lung diseases such as pulmonary fibrosis has long been recognized, and modern clinical application has further shown that Baiji alone has a good therapeutic effect on tuberculosis and silicosis, and combined with anti-tube...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P11/00A61P29/00A61K125/00
CPCA61K36/898A61K2236/333A61K2236/55A61P11/00A61P29/00
Inventor 蒋福升李美芽丁志山丁兴红李松涛窦晓兵吕圭源
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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