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Phenanthrene compound in junci medulla as well as preparation method and application of phenanthrene compound

A technology of rushes and compounds, which is applied in the field of phytochemistry, can solve problems such as no relevant reports on the application, and achieve good application prospects

Inactive Publication Date: 2018-11-09
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no relevant report on the compound and its application

Method used

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  • Phenanthrene compound in junci medulla as well as preparation method and application of phenanthrene compound
  • Phenanthrene compound in junci medulla as well as preparation method and application of phenanthrene compound
  • Phenanthrene compound in junci medulla as well as preparation method and application of phenanthrene compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A preparation method of phenanthrene compounds in rushes, comprising the following steps:

[0053] Step (1), extract extraction: pulverize the whole dried rush grass to 30-50 mesh, use 70% ethanol aqueous solution by volume as the extraction solvent, extract multiple times at room temperature, 6h each time, combine the extracts, filter , get the filtrate and concentrate under reduced pressure to obtain the extract;

[0054] Step (2), silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and carry out gradient elution with petroleum ether and acetone mixed organic solvent, and the volume ratios are 10:1, 10:3, 10:5, 10:6, 10:7, 10:9 and 10:10, after each gradient elution to the TLC spot plate without spots, the next gradient elution was replaced; the gradient eluents of each gradient were collected and concentrated , monitored by TLC, merged the same parts to obtain seven parts A1-A7;

[0055] Step (3), separation b...

Embodiment 2

[0057] A preparation method of phenanthrene compounds in rushes, comprising the following steps:

[0058] Step (1), extract extraction: pulverize the whole dried rush grass to 30-50 mesh, use 70% ethanol aqueous solution by volume as the extraction solvent, extract twice at room temperature, 6h each time, combine the extracts, filter , take the filtrate and concentrate under reduced pressure to obtain the extract; the volume of the ethanolic aqueous solution and the mass ratio of the dried rush grass in each extraction is 50L: 25Kg;

[0059] Step (2), silica gel column chromatography: the extract obtained in step (1) is dissolved in an aqueous methanol solution with a volume percent concentration of 1.5 times the weight of the extract, which is 95%, and then mixed with 100-mesh silica gel with 2 times the quality of the extract. The sample was then subjected to silica gel column chromatography, the silica gel for packing the column was 200 mesh, and the weight of the silica ge...

Embodiment 3

[0064] A preparation method of phenanthrene compounds in rushes, comprising the following steps:

[0065] Step (1), extract extraction: pulverize the whole dried rush grass to 30-50 mesh, use 95% ethanol aqueous solution by volume as the extraction solvent, extract 4 times at room temperature, 10 hours each time, combine the extracts, filter , take the filtrate and concentrate under reduced pressure to obtain the extract; the volume of the ethanolic aqueous solution and the mass ratio of the dried rush grass in each extraction is 50L: 25Kg;

[0066] Step (2), silica gel column chromatography: the extract obtained in step (1) is dissolved in an aqueous methanol solution with a volume percentage concentration of 4 times the weight of the extract, which is 95%, and then mixed with 100-mesh silica gel with 4 times the weight of the extract. The sample was then subjected to silica gel column chromatography, the silica gel for packing the column was 300 mesh, and the weight of the s...

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Abstract

The invention relates to a phenanthrene compound in junci medulla as well as a preparation method and application of the phenanthrene compound, belonging to the technical field of phytochemistry. Thestructural formula of the compound is represented by a formula (I) (shown in the description). The phenanthrene compound is separated from all grass of the junci medulla for the first time and is determined as the phenanthrene compound by virtue of a magnetic resonance imaging and mass spectrum determination method, and a specific structure of the phenanthrene compound is represented. The phenanthrene compound presents certain antifungal activity for resisting bipolaria maydis and eggplant phytophthora rot, the lowest inhibition concentrations are 50microg / mL, meanwhile, the phenanthrene compound presents certain bacterial activity for resisting bacterium paratyphosum B and drug-resistant staphylococcus aureus, and the lowest inhibition concentrations are 100microg / mL, so that the phenanthrene compound has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a phenanthrene compound in rushes and a preparation method and application thereof. Background technique [0002] Rush, Chinese medicinal name, is a perennial herbaceous aquatic plant, with short underground stems, creeping, stalks erect, cylindrical, solid, with brown at the base of the stem, reduced to scale-like sheath leaves, spike-like inflorescences, terminal, on the stem. Pseudolateral, basal bracts extend stem-like, with 2 bracteoles under the flower, 6 perianth lobes, 3 stamens, and 3 divergent pistil stigmas. Brown-yellow capsules, ovate or elliptic, seeds yellow obovate. Rush is also a medicinal plant. Its stem pith or the whole herb is used as medicine to clear heat, diuretic water and infiltrate dampness. It can be used for gonorrhea, edema, restlessness, insomnia, sore throat and trauma. [0003] The phenanthrene compound is a condensed aromatic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/17C07C37/82C07C37/68A61P31/04A61P31/10
CPCA61P31/04A61P31/10C07C37/004C07C37/685C07C37/82C07C39/17C07C2603/50
Inventor 巩效伟赵伟洪鎏朱东来张霞李寿波李廷华吴俊韩熠陈永宽
Owner CHINA TOBACCO YUNNAN IND
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