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Method for preparing hydrogel surgical dressing and application of hydrogel surgical dressing

A hydrogel medicine and cross-linking reaction technology, applied in medical science, bandages, etc., can solve the problems of sodium alginate and gelatin with weak antibacterial properties, limited healing performance, and fast gelation speed, etc., to achieve the purpose of inhibiting bacteria Effects of growth, promotion of cell metabolism, and promotion of healing

Inactive Publication Date: 2018-11-13
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But directly adding Ca 2+ Cross-linking reaction, the gelation speed is fast, the obtained gel is extremely uneven, resulting in unstable strength; and the antibacterial properties of sodium alginate and gelatin are not strong, and the performance of promoting wound healing is limited

Method used

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  • Method for preparing hydrogel surgical dressing and application of hydrogel surgical dressing
  • Method for preparing hydrogel surgical dressing and application of hydrogel surgical dressing
  • Method for preparing hydrogel surgical dressing and application of hydrogel surgical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Dissolve 0.675g of alginic acid and 0.4435g of rubidium carbonate in 25ml of deionized water, and react with magnetic stirring for 30min at 40°C and a stirring speed of 400r / min (a large number of bubbles are generated during the reaction process, and as the reaction time prolongs, the bubbles gradually disappear), to obtain rubidium alginate solution.

[0026] Dissolve 0.1520g of sodium alginate in 5ml of deionized water to obtain a sodium alginate solution, then add 5ml of rubidium alginate solution to the sodium alginate solution, then stir magnetically at 40°C and 400r / min for 20min, Mix the two evenly to obtain an alginate solution.

[0027] 0.0829 g of calcium carbonate was dispersed in 5 ml of 40° C. deionized water to obtain a dispersion. Pour 5ml of the dispersion into the alginate solution (10ml), and mix well to obtain a pre-crosslinking solution.

[0028] Add 0.3248g of gluconolactone GDL to the above-mentioned pre-crosslinking solution (15ml), and conduct...

Embodiment 2

[0034] Dissolve 0.675g of alginic acid and 0.4435g of rubidium carbonate in 25ml of deionized water, and react with magnetic stirring for 30min at 40°C and a stirring speed of 400r / min (a large number of bubbles are generated during the reaction process, and as the reaction time prolongs, the bubbles gradually disappear), to obtain rubidium alginate solution.

[0035] 0.0829 g of calcium carbonate was dispersed in 5 ml of 40° C. deionized water to obtain a dispersion. Pour 5ml of the dispersion liquid into the rubidium alginate solution (10ml), and mix well to obtain a pre-crosslinking solution.

[0036] Add 0.3248g of gluconolactone GDL to the above-mentioned pre-crosslinking solution (15ml), and conduct a crosslinking reaction for 0.5h at a stirring speed of 300r / min. After the reaction is completed, a hydrogel medical auxiliary material 100Rb-CA is obtained.

Embodiment 3

[0038] (1) Infrared spectrum analysis

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Abstract

The invention discloses a method for preparing a hydrogel surgical dressing, and the method comprises the steps that alginic acid and rubidium carbonate are dissolved in water, magnetic stirring action is performed at set temperature, and after reaction, a rubidium alginate solution is obtained; the rubidium alginate solution is dissolved in water to obtain a sodium alginate solution, then the sodium alginate solution is mixed with the rubidium alginate solution, and an alginate solution is obtained; after calcium carbonate is uniformly dispersed into water, a dispersion solution is obtained,the dispersion solution is added to the alginate solution or the sodium alginate solution and stirred and mixed uniformly, and a pre-crosslinked solution is obtained; glucolactone is added to the pre-crosslinked solution, then cross-linking reaction is performed under the stirring condition, and the hydrogel surgical dressing is obtained after the reaction. According to the method for preparing the hydrogel surgical dressing and application of the hydrogel surgical dressing, the functions of oxidation resistance, cell metabolism promotion and bacteria growth inhibition of the rubidium ions areused, the rubidium ions are introduced into hydrogel, the antibacterial property of the hydrogel is enhanced, the cell growth can be accelerated, and wound surface healing is promoted.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a preparation method and application of a hydrogel medical dressing. Background technique [0002] The rise of hydrogel dressings benefited from a major conceptual breakthrough in wound healing in the 1980s. Previous treatments believed that wounds need to breathe, and maintaining the air permeability of wounds is an important factor for ideal dressings, but new research proves that an oxygen-free atmospheric environment can promote the proliferation of blood vessels, thereby accelerating wound healing. Hydrogel dressings have been widely valued due to their advantages of automatically adjusting the moisture of the wound, absorbing a small amount of exudate, not sticking to the wound, and being easy to remove. [0003] At present, sodium alginate hydrogel is a kind of hydrogel dressing, because it has good biocompatibility and moisture retention, it has a g...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/102A61L2300/404A61L2300/412C08L5/04
Inventor 刘咏和祥谭彦妮
Owner CENT SOUTH UNIV
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