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Preparation method of anti-allergic antibacterial cream

An allergic and anti-allergic technology, which is applied in the direction of antibacterial drugs, allergic diseases, medical preparations of non-active ingredients, etc., can solve the problems of skin irritation, easy separation, and difficulty in dispersing, and achieve good hydrophilicity and affinity Skin-friendly, wide-ranging effects

Inactive Publication Date: 2021-12-24
泰兴瑞深新材科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of nanotechnology and nanotechnology, the application of metal particles has been widely used in recent years, mainly as nanoparticles. Due to the different antibacterial mechanisms, bacterial resistance has hardly been reported, so it can be used as a substitute for antibiotics. ; But these inorganic antibacterial agents are difficult to disperse, easy to separate, have poor biocompatibility, and have the problem of irritation to the skin

Method used

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  • Preparation method of anti-allergic antibacterial cream
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of preparation method of antiallergic antibacterial ointment, its preparation scheme step is:

[0025] Step a, preparation of anti-allergic modified zinc oxide nanoparticles:

[0026] For cyanation modification, add 6.8g of zinc oxide nanoparticles to 100g of n-heptane, stir and disperse evenly, add 3.8g of 2-cyanoethyltriethoxysilane to the reaction kettle, control the temperature to 80°C, and stir React for 5 hours, filter after completion, and dry after washing to obtain cyanation-modified zinc oxide nanoparticles;

[0027] Carboxylation modification, disperse 5.5g cyanation modified zinc oxide nanoparticles into 150g ethanol, then add 8.2g sulfuric acid solution with a mass fraction of 50%, control the temperature at 70°C, react for 4h, filter and wash after completion , and dry to obtain carboxylated modified zinc oxide nanoparticles;

[0028] Anti-allergic modification, disperse 4.5g carboxylated modified zinc oxide nanoparticles in 80g water, then config...

Embodiment 2

[0035] A kind of preparation method of antiallergic antibacterial ointment, its preparation scheme step is:

[0036] Step a, preparation of anti-allergic modified zinc oxide nanoparticles:

[0037] For cyanation modification, add 8.4g of zinc oxide nanoparticles to 150g of n-heptane, stir and disperse evenly, add 6.8g of 2-cyanoethyltriethoxysilane into the reaction kettle, control the temperature to 85°C, and stir React for 8 hours, filter after completion, and dry after washing to obtain cyanation-modified zinc oxide nanoparticles;

[0038] Carboxylation modification, disperse 7.5g cyanation modified zinc oxide nanoparticles into 220g ethanol, then add 12.8g sulfuric acid solution with a mass fraction of 65%, control the temperature at 75°C, react for 6h, filter and wash after completion , and dry to obtain carboxylated modified zinc oxide nanoparticles;

[0039] Anti-allergic modification, disperse 6.8g carboxylated modified zinc oxide nanoparticles in 100g water, then co...

Embodiment 3

[0046] A kind of preparation method of antiallergic antibacterial ointment, its preparation scheme step is:

[0047] Step a, preparation of anti-allergic modified zinc oxide nanoparticles:

[0048] For cyanation modification, add 10.2g of zinc oxide nanoparticles to 180g of n-heptane, stir and disperse evenly, add 12.6g of 2-cyanoethyltriethoxysilane to the reaction kettle, control the temperature to 95°C, and stir React for 10 hours, filter after completion, and dry after washing to obtain cyanated modified zinc oxide nanoparticles;

[0049] Carboxylation modification, disperse 9.5g cyanation modified zinc oxide nanoparticles into 280g ethanol, then add 16.4g sulfuric acid solution with a mass fraction of 75%, control the temperature at 80°C, react for 8h, filter and wash after completion , and dry to obtain carboxylated modified zinc oxide nanoparticles;

[0050] Anti-allergic modification, disperse 8.8g carboxylated modified zinc oxide nanoparticles in 120g water, then co...

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Abstract

The invention relates to a preparation method of anti-allergic antibacterial cream. The preparation method comprises the following steps of: preparing anti-allergic modified zinc oxide nanoparticles, performing cross-linking modification on a polyvinyl alcohol dispersion and the like. The anti-allergic antibacterial cream provided by the invention uses the anti-allergic modified zinc oxide nanoparticles coated with polylysine, the antibacterial property of the antibacterial material is obviously superior to that of common commercial zinc oxide nanoparticles, and the antibacterial material has better hydrophilicity and skin friendliness, is non-toxic and non-irritating, and does not easily cause skin allergy; and the prepared antibacterial cream has wide application in the fields of medical treatment and cosmetics.

Description

technical field [0001] The invention relates to a method for preparing an antiallergic antibacterial ointment, which belongs to the field of preparation of medical antibacterial drugs. Background technique [0002] Antibiotics have been widely used in the field of antibacterial, and with the development of public health and biomedical technology, many infections have been effectively suppressed or even overcome, and the quality of human life has been significantly improved. However, a problem that is difficult to solve is that the use of antibiotics has led to The emergence of multidrug-resistant microorganisms, which also leads to more than 13 million deaths from infectious diseases every year, is most disappointing because once the latest antibiotics are used, the corresponding drug-resistant bacteria appear almost immediately. [0003] Inorganic metal silver has been used as an antibacterial agent thousands of years ago. Silver powder was first recorded in medical history...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K33/30A61K31/785A61K47/34A61K9/50A61P31/04A61P37/08
CPCA61K9/06A61K33/30A61K31/785A61K47/34A61K9/5031A61P31/04A61P37/08A61K2300/00
Inventor 不公告发明人
Owner 泰兴瑞深新材科技有限公司
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