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Compound ginkgo external seed coat oil agent preparation method

A technology of Ginkgo biloba exotesta and oil agent, which is applied in the direction of medical raw materials derived from Ginkgo biloba, medical preparations containing active ingredients, anti-inflammatory agents, etc., to achieve the effects of increasing viscosity, reducing the amount of products used, and prolonging the time

Inactive Publication Date: 2018-11-30
PIZHOU GAXING MEDICINE TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to literature reports, there is no published patent application and related literature reports on the preparation method of ginkgo biloba testa and Wuducao compound oil preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]Separately take 150g of ginkgo testa and 150g of five poisonous grasses after being fully dried, grind them into coarse powder, mix them evenly, put them into a container with a cover, add 300g of ethanol with a concentration of 75% v / v, moisten them evenly, and cover them Place it for 24 hours, put it in the percolation cylinder and place it for 24 hours, then percolate, and adjust the flow rate to 1ml min -1 , add 75% v / v ethanol from the top of the percolation cylinder, collect 1000g of the filtrate, and store it in another device; add 3000g of distilled water to the percolation residue, decoct and extract for 1.5h, filter the water extract, and add 12000g of 95% v / v Ethanol, stir evenly, put it at 1-2°C for 24 hours, filter to obtain the extract; combine the extract with the above percolation liquid, heat on a water bath to recover the ethanol until it has no alcohol smell, continue to concentrate into a thick paste, and Put the thick paste in an oven and dry at 110°...

Embodiment 2

[0021] Separately take 350g of ginkgo testa and 350g of five poisonous grasses after being fully dried, grind them into coarse powder, mix them evenly, put them into a container with a cover, add 700g of ethanol with a concentration of 75% v / v, moisten them evenly, and cover them Place it for 24 hours, put it in the percolation cylinder and place it for 24 hours, then percolate, and adjust the flow rate to 1ml min -1 , add 75% v / v ethanol from the top of the percolation cylinder, collect 1000g of the filtrate, and store it in another device; add 7000g of distilled water to the residue, decoct and extract for 1.5h, filter the water extract, and add 28000g of 95% v / v Ethanol, stir evenly, put it at 1-2°C for 24 hours, filter to obtain the extract; combine the extract with the above percolation liquid, heat on a water bath to recover the ethanol until it has no alcohol smell, continue to concentrate into a thick paste, and Put the thick paste in an oven and dry at 110°C until the...

Embodiment 3

[0023] Separately take 200g of ginkgo testa and 200g of five poisonous grasses after being fully dried, grind them into coarse powder, mix them evenly, put them into a container with a cover, add 400g of ethanol with a concentration of 75% v / v, moisten them evenly, and cover them Place it for 24 hours, put it in the percolation cylinder and place it for 24 hours, then percolate, and adjust the flow rate to 1ml min -1 , add 75% v / v ethanol from the top of the percolation cylinder, collect 1000g of filtrate, and store in another container; add 4000g of distilled water to the residue, decoct and extract for 1.5h, filter the water extract, add 16000g of 95% v / v Ethanol, stir evenly, put it at 1-2°C for 24 hours, filter to obtain the extract; combine the extract with the above percolation liquid, heat on a water bath to recover the ethanol until it has no alcohol smell, continue to concentrate into a thick paste, and Put the thick paste in an oven and dry it at 110°C until the wate...

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PUM

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Abstract

The invention provides a compound ginkgo external seed coat oil agent preparation method, and belongs to the field of preparation of traditional Chinese medicines, wherein per 1 kg of the compound ginkgo external seed coat oil agent are prepared from 150-350 g of ginkgo external seed coat, 150-350 g of Polygonum sinense L, 5-25 g of borneol, and the balance of vegetable oil. According to the present invention, the ginkgo external seed coat and the Polygonum sinense L have pharmacological effects of heat clearing, detoxification, antibacterial effect, anti-inflammatory effect, swelling subsiding, pain stopping, itching stopping and the like, the effective components of the two herbs can be completely extracted by combining ethanol percolation, water decoction and alcohol precipitation, andthe two herbs and the vegetable oil are uniformly mixed and grinded to prepare the oil agent product; the affected area is coated with the prepared compound oil agent during the use so as to mainly kill various bacteria and fungi, and simultaneously achieve effects of inflammation eliminating and itching stopping; the product has good synergistic treatment effects on dermatitis, neurodermatitis, eczema, tinea pedis and tinea manus, versicolor pityriasis, tinea corporis and the like; and the new preparation method for preparing the oil agent product through the mixed extraction of ginkgo external seed coat and Polygonum sinense L is provided.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparation and relates to a preparation method of compound ginkgo exocarp oil. Background technique [0002] Ginkgo biloba seed coat is the outer part of the hard shell of ginkgo tree seeds (i.e. ginkgo), commonly known as ginkgo coat. The Ginkgo exocarp is the fleshy exocarp of the Ginkgo seed. Scientists have found through research that the outer testa contains a large amount of hydrogenated ginkgolic acid, ginkgool and ginkgool, and also contains ginkgoxanthin, isoginkkoxanthin and polysaccharides, as well as trace amounts of ginkgolides. Its action properties are similar to those of cyclophosphamide and dexamethasone. The polysaccharides in the exotesta of Ginkgo biloba can enhance the function of cellular immunity, and have effects on the production of B lymphocytes and the formation of antibodies in the process of humoral immunity. According to literature reports, the alcohol ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61K9/08A61P17/00A61P31/02A61P31/10A61P29/00A61P17/04A61P17/16A61K31/045
CPCA61K36/70A61K9/0014A61K9/08A61K31/045A61K36/16A61K47/44A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P17/00A61P17/04A61P17/16A61P29/00A61P31/02A61P31/10A61K2300/00
Inventor 张奎昌花丽汤先伟张路
Owner PIZHOU GAXING MEDICINE TECH SERVICE CO LTD
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