Model establishment and evaluation method for nephritic syndrome rats
A technology of nephrotic syndrome and rat models, applied in medical simulation, character and pattern recognition, special data processing applications, etc., can solve problems such as poor accuracy and low sensitivity, achieve strong specificity, reflect rationality and scientific Effect
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[0024] A construction method of nephrotic syndrome rat model, comprising the following steps:
[0025] (1) Rats were injected with 4 mg / kg of doxorubicin into the tail vein on the first day, and then 1 mg / kg of doxorubicin was injected into the tail vein on the eighth day to obtain a rat model of doxorubicin nephropathy;
[0026] (2) Multivariate statistical analysis method was used to characterize the metabolic profile, principal component analysis (PCA) was used to identify the pattern of the data, and the separation of the data profiles of each group was investigated. The specific method is to collect the urine of the rat model respectively in the 0th week, the 2nd week, the 4th week, and the 6th week of the rat model construction, and first collect the urine of the 0th week, the 2nd week, the 4th week, and the 6th week. The collected urine of the rat model was analyzed by nuclear magnetic resonance, and the results of the rat model were obtained. 1 H NMR spectrum; then th...
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