Activation test for diagnosis of heparin-induced thrombocytopenia

A technology of platelets and heparin, applied in disease diagnosis, biological testing, material inspection products, etc., can solve the problems of not being able to perform functional test principles in an automatic way, complex manual operations, etc.
CN109030816BActive Publication Date: 2021-09-17SIEMENS HEALTHCARE DIAGNOSTICS PRODS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SIEMENS HEALTHCARE DIAGNOSTICS PRODS
Publication Date
2021-09-17

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Abstract

The present invention relates to an activation test for the diagnosis of heparin-induced thrombocytopenia. In particular, the present invention relates to a functional, easily automated assay for the determination of heparin-induced thrombocytopenia (HIT). It measures the secretion of PF4 (platelet factor 4) from activated platelets.
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Description

technical field

[0001] The present invention is in the field of in vitro diagnostics and relates to a functional, easily automatable test for the determination of heparin-induced thrombocytopenia. Background technique

[0002] Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder that may occur during heparin therapy and may result in life-threatening thromboembolic complications. Patients produce antibodies that bind to a complex of heparin and platelet factor 4 (PF4), known as anti-PF4 / heparin complex antibodies. In vivo, the antibody-bound PF4 / heparin complex binds to the platelet surface and causes activation of the platelet. This results in a decrease in platelet counts and an increased risk of thromboembolism.

[0003] There are two main test principles used in the diagnosis of HIT. The first test principle is based on the direct detection of anti-PF4 / heparin complex antibodies in a patient's body fluid sample. To this end, the sample is contacted with a ...

Claims

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