Anti-RSV application of pf4

A technology of application and platelet factor, which can be used in medical preparations containing active ingredients, antiviral agents, peptide/protein components, etc., which can solve the problem that the antiviral function of PF4 is rarely studied.
CN108926707BActive Publication Date: 2021-12-03INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
Publication Date
2021-12-03

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Abstract

The anti-RSV application of PF4 discloses that the platelet factor 4 can alleviate the symptoms of virus infection by inhibiting the replication of respiratory syncytial virus in the host body, and is an effective anti-respiratory syncytial virus infection intervention measure. The invention provides the use of platelet factor 4 in the preparation of medicines for preventing and / or treating diseases and / or symptoms caused by respiratory syncytial virus infection, and also provides administration routes, dosage forms and medicines suitable for the medicines. Combination with other drugs, etc.; In addition, it also provides a non-therapeutic method for inhibiting respiratory syncytial virus in cells in vitro with platelet factor 4.
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Description

technical field

[0001] The present invention relates to respiratory syncytial virus, and in particular to antiviral interventions useful for the prevention and / or treatment of diseases and / or symptoms caused by the virus. Background technique

[0002] Respiratory syncytial virus (Respiratory Syncytial Virus, RSV) belongs to Paramyxoviridae Pneumoviridae subfamily Pneumovirus, is an enveloped single-stranded negative-sense RNA virus, the genome encodes a total of 11 viral proteins, from 3' to 5' Nonstructural protein 1 (NS1), nonstructural protein 2 (NS2), nucleocapsid protein (N), phosphoprotein (P), matrix protein (M), small hydrophobin (SH), glycoprotein (G) , fusion protein (F), M2ORF1 / ORF2 protein (M2-1 / M2-2) and large protein (L). RSV is distributed worldwide and has only one serotype. It can be divided into two subgroups, A and B, according to antigen reactivity. Subgroup A is prevalent in most parts of the world (Griffiths C, Drews S J, Marchant D J. Respiratory Sync...

Claims

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