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A kind of autism serum polypeptide marker apoc1‑a and its application

A technology of APOC1-A and serum peptides, which is applied in the fields of peptides, decapeptides, biological tests, etc., and can solve the problems of lack of quantifiable indicators

Inactive Publication Date: 2017-10-20
广东辰辉生物医学技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The diagnosis of the disease originated from the observation of clinical symptoms of a group of patients. Since the diagnosis of autism, the diagnostic criteria have been revised many times due to the lack of quantifiable indicators.

Method used

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  • A kind of autism serum polypeptide marker apoc1‑a and its application
  • A kind of autism serum polypeptide marker apoc1‑a and its application
  • A kind of autism serum polypeptide marker apoc1‑a and its application

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Embodiment Construction

[0022] The autism serum polypeptide molecule provided by the invention is a newly screened autism serum diagnostic marker, its expression has specificity, and can be applied to autism diagnosis. The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0023] The specific screening of the serum diagnostic markers for autism is as follows:

[0024] First, the liquid protein chip technology was used to separate and extract the serum protein peptides of children with autism and normal controls, and MALDI-TOF-MS was used to capture the protein and peptide profiles of children with autism and normal controls, and the software ClinProTools2.1 was used to compare and analyze the protein peptides of children with autism. The differences in the serum protein and polypeptide spectra of children and normal people were used to find out the scores of protein polypeptid...

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Abstract

The invention discloses an ASD (autism spectrum disorders) serum polypeptide marker APOC1-A and an application thereof. An amino acid sequence of the ASD serum polypeptide marker APOC1-A is shown in SEQ.ID.NO.1. A molecule is called as APOC1-A, is a fragment of a platelet factor 4(APOC1) and has an accurate molecular weight being 6,638 Dalton. APOC1-A shows remarkable high expression in serum examination of children suffering from ASD, APOC1-A is detected through an MALDI-TOF-MS (matrix assisted laser desorption ionization / time-of-flight mass spectrometer) or the expression level of APOC1 is detected with an ELISA (enzyme-linked immunosorbent assay) method, and the ASD serum polypeptide marker APOC1-A can be used for detection of ASD serums.

Description

technical field [0001] The invention belongs to the technical field of autism detection, and relates to a novel autism serum polypeptide marker APOC1-A and application thereof. Background technique [0002] Autism, also known as Autism Spectrum Disorders (ASD), is a generalized neurodevelopmental disorder characterized by loss of social function, abnormal verbal and nonverbal communication, and stereotyped limitations of behavior and interests. The rate is about 1%. Generally, the onset occurs in early childhood before the age of 3 and lasts for life. The incidence rate of boys is 4 to 6 times that of girls. Research shows that early diagnosis and screening for ASD can help increase the chances that children with autism will benefit from early intervention. However, due to the lack of biomarkers, the current screening and diagnosis of ASD is mainly based on children's behavioral characteristics and developmental history, so there is controversy, and there is an urgent need...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/00G01N33/68
CPCG01N30/02G01N33/68G01N33/6851G01N2030/027
Inventor 黄辰杨娟宋土生
Owner 广东辰辉生物医学技术有限公司
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