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Application of biological sleeve in cardiac implantation of electronic instruments

A biological and cardiac technology, applied in cardiac stimulators, electrotherapy, animal cells, etc., can solve problems such as equipment movement, infection of the pouch, frictional bleeding into hematoma, etc., to reduce the incidence of rupture of the pouch and reduce inflammation. and infection, good biocompatibility

Pending Publication Date: 2019-01-04
上海白衣缘生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) The shell of the device is made of titanium or other alloys, which is always a foreign body to the human body and can cause the body to produce rejection reactions
[0006] (2) Some reasons can cause the device to move, such as the patient's age, weight loss, thin skin, too large pouch, physical activity, etc., and the movement of the device can easily lead to friction bleeding into hematoma, friction and skin ulceration
[0007] (3) Implantation or replacement of equipment may easily cause pouch infection
[0009] The Chinese utility model patent with the publication number CN 202437991U is currently the only patent retrieved that involves solving the complications of CIED implantation. The silicone rubber layer, the outer layer is the hydroxyapatite layer coated on the silicone rubber, which only protects the equipment and fails to remove the main cause of the complications related to the capsular bag, so it fails to reduce the complications related to the capsular bag incidence of

Method used

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  • Application of biological sleeve in cardiac implantation of electronic instruments
  • Application of biological sleeve in cardiac implantation of electronic instruments
  • Application of biological sleeve in cardiac implantation of electronic instruments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] (1) Pretreatment

[0062] Freshly slaughtered porcine small intestine tissue was cleaned and soaked in 0.5% acetic acid solution for 30 minutes. The ratio of porcine small intestine to acetic acid solution was 1:5, and the mucosal layer, muscular layer and serosa layer of porcine small intestine and jejunum were removed by physical scraping , Lymph nodes, the submucosa was separated, cut into pieces, and washed 3 times with purified water;

[0063] (2) Disinfection

[0064] Use a mixed aqueous solution containing 1.0% peracetic acid and 15% ethanol, the ratio of SIS (small intestinal submucosa) material to the mixed aqueous solution is 1:10, and soak at room temperature for 100 minutes under ultrasonic conditions for disinfection. Then use purified water to ultrasonically clean 3 times;

[0065] (3) Degreasing and decellularization

[0066] Use ethanol with a concentration of 95%, the ratio of SIS material to ethanol is 1:10, and soak at room temperature for 2 hours ...

Embodiment 2

[0071] (1) Pretreatment

[0072] Freshly slaughtered porcine small intestine tissue was cleaned and soaked in 0.5% acetic acid solution for 30 minutes. The ratio of porcine small intestine to acetic acid solution was 1:5, and the mucosal layer, muscular layer and serosa layer of porcine small intestine and jejunum were removed by physical scraping , Lymph nodes, the submucosa was separated, cut into pieces, and washed 3 times with purified water;

[0073] (2) Disinfection

[0074] Use a mixed aqueous solution containing 1.0% peracetic acid and 15% ethanol, the ratio of the SIS material to the mixed aqueous solution is 1:10, and immerse at room temperature for 100 minutes under ultrasonic conditions for disinfection. Then use purified water to ultrasonically clean 3 times;

[0075] (3) Degreasing

[0076] Use ethanol with a concentration of 95%, the ratio of SIS material to ethanol is 1:10, and soak at room temperature for 2 hours under ultrasonic conditions. Then use water...

Embodiment 3

[0083] (1) Pretreatment

[0084] Freshly slaughtered porcine small intestine tissue was cleaned and soaked in 0.5% acetic acid solution for 30 minutes. The ratio of porcine small intestine to acetic acid solution was 1:5, and the mucosal layer, muscular layer and serosa layer of porcine small intestine and jejunum were removed by physical scraping , Lymph nodes, the submucosa was separated, cut into pieces, and washed 3 times with purified water;

[0085] (2) Virus inactivation

[0086] Use a mixed aqueous solution containing 1.0% peracetic acid and 15% ethanol, the ratio of the SIS material to the mixed aqueous solution is 1:10, and soak at room temperature for 100 minutes under ultrasonic conditions to inactivate the virus. Then use purified water to ultrasonically clean 3 times;

[0087] (3) Degreasing

[0088] Use ethanol with a concentration of 95%, the ratio of SIS material to ethanol is 1:10, and soak at room temperature for 2 hours under ultrasonic conditions. Then...

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Abstract

The invention discloses an application of a biological sleeve in cardiac implantation of an electronic instrument, which is used for inserting a pulse generator of a cardiac implantable electronic instrument such as a cardiac pacemaker and a defibrillator, and then implanting the pulse generator into a capsule formed by subcutaneous tissue together. As the biological sleeve is an acellular matrix,the biological sleeve has good biocompatibility, certain mechanical property, biodegradability, antibacterial ability and the like, and can reduce the incidence of complications such as capsule infection, hematoma, ulceration and the like after cardiac implantation of electronic instruments.

Description

technical field [0001] The invention relates to the field of bioabsorbable implant medical devices, in particular to the application of a biological sleeve in electronic device heart implantation. Background technique [0002] Cardiac implantable electronic devices (CIED) include implantable cardiac pacemakers (ICP), implantable cardioverter defibrillators (ICD), cardiac resynchronization therapy devices (CRT) and implantable cardiac monitors ( ICM), etc., are mainly used for the diagnosis, treatment and monitoring of bradycardia, tachycardia and heart failure. CIED is generally composed of a pulse generator, electrodes and wires. The pulse generator with power supply is generally packaged with a titanium metal shell by laser welding, and is directly implanted into the pouch formed by the subcutaneous tissue in front of the pectoralis major muscle. The wire used as the conduction part is A length of metal wire covered with an insulating material, and the electrode is implan...

Claims

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Application Information

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IPC IPC(8): A61N1/372A61N1/375A61L27/36A61L27/58A61L27/54A61L27/50C12N5/071
CPCA61L27/3633A61L27/50A61L27/54A61L27/58A61L2300/406A61L2300/412A61N1/362A61N1/372A61N1/37512C12N5/0602
Inventor 韩韦红葛翠兰钱锵
Owner 上海白衣缘生物工程有限公司
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