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A pharmaceutical composition for treating ischemic stroke and application thereof

A technology for ischemic stroke and composition, applied in the field of natural medicinal chemistry, can solve problems such as limited treatment methods, achieve high development potential, reduce water content, and improve neurological function scores.

Inactive Publication Date: 2019-01-11
苏州博柱生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment methods for ischemic stroke are very limited. Since the pharmaceutical composition has a synergistic effect of the interaction between the components and has the characteristics of multi-target action, it has great potential in the prevention and treatment of ischemic stroke. Therefore, there is an urgent need for a multi-pronged method of "prevention, supplementation and treatment", which can improve the brain damage caused by cerebral ischemia in time, and can achieve the effect of preventing and treating ischemic stroke.

Method used

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  • A pharmaceutical composition for treating ischemic stroke and application thereof
  • A pharmaceutical composition for treating ischemic stroke and application thereof
  • A pharmaceutical composition for treating ischemic stroke and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The parts by weight of diosgenin are 8, the parts by weight of Panax notoginseng saponins are 6, the parts by weight of geniposide are 6, and the parts by weight of isoameric chinenol A are 6, the above compounds are mixed, Emulsified to make oral solution.

Embodiment 2

[0026] The parts by weight of diosgenin are 10, the parts by weight of Panax notoginseng saponins are 8, the parts by weight of geniposide are 9, and the parts by weight of isoameric polyphenol A are 10, and the above compounds are added to stearyl Magnesium acid is mixed and compressed into tablets.

[0027] In the present invention, the pharmaceutical composition can be made into dosage forms such as tablets, capsules and pills, or it can also be prepared into a solution, and its drug effect is verified by the following drug effect test.

experiment example 1

[0029] Therapeutic effect of the composition of the present invention on rats with ischemic stroke

[0030] Healthy adult SD rats, male, clean grade, weighing 300-350 g, provided by the Drug Safety Evaluation Center (GLP) of Heilongjiang University of Traditional Chinese Medicine, animal use license number: SCXK2014-004, kept at room temperature, free to eat and drink.

[0031] KDC-160HR high-speed refrigerated centrifuge (HKUST Innovation Co., Ltd.); BL-420F biological function experiment system (Chengdu Taimeng Software Co., Ltd.); AL204 electronic balance (Mettler-Toledo Instrument Shanghai Co., Ltd.); LBY-NJ2 Platelet aggregation instrument (Beijing Prism Instrument Co., Ltd.); DK-98-11A electric heating constant temperature water bath (Tianjin Tester Instrument Co., Ltd.); KDC-160R high-speed refrigerated centrifuge (Keda Innovation Co., Ltd. Zhongjia Branch) .

[0032] A pharmaceutical composition for treating ischemic stroke of the present invention (make the compositi...

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Abstract

The invention provides a pharmaceutical composition for treating ischemic stroke, comprising diosgenin, panax notoginseng saponins, geniposide and isocalcophenol A, wherein the weight parts of the diosgenin are 8-15 part by weight of panax notoginseng total saponins, 6 part by weight of panax notoginseng total saponins, 6 parts by weight of panax notoginseng total saponins, 6 parts by weight of panax notoginseng total saponins, 6 parts by weight of panax notoginseng total saponins, 12 part by weight of geniposide, 6 parts by weight of geniposide-12, part by weight of iso-pheromone A is 6-12, that pharmaceutical composition can be use for improving the therapeutic effect of brain injury due to cerebral ischemia. The pharmaceutical composition is derived from natural medicine, has compatibility of various drugs, synergistic effect, remarkably improved pharmacodynamic activity, simple preparation, and high development potential.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating ischemic stroke and its application, belonging to the technical field of natural medicinal chemistry. Background technique [0002] Ischemic stroke has become the number one killer of human health. Stroke is a cerebrovascular disease. Thrombosis and cerebrovascular blockage are caused by one or some other reasons, and the microcirculation of the brain is damaged, and the blood supply to the brain is insufficient, which eventually leads to damage of brain cells and destruction of brain function. With the improvement of people's material living standards, intake of more sugar, fat, etc., coupled with unhealthy lifestyles, the number of people suffering from cerebrovascular diseases is gradually increasing and getting younger, which has become a threat to human health, causing disability and The number one killer of death. According to statistics, the morbidity and mortality of stroke in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61K31/7048A61K31/704A61K31/357
CPCA61K31/357A61K31/704A61K31/7048A61K36/258A61P9/10A61K2300/00
Inventor 不公告发明人
Owner 苏州博柱生物科技有限公司
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