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A Chinese medicinal composition for improving memory loss and alleviate senile dementia and its preparation method

A technology for senile dementia and composition, which is applied in the field of pharmaceutical composition for improving memory loss and alleviating senile dementia and its preparation, which can solve the problems of side effects and dependence of chemical drugs, and achieve the prevention of cardiovascular and cerebrovascular diseases, strengthening the excitement process, The effect of promoting blood circulation

Inactive Publication Date: 2019-01-18
BEIJING CHENGYI INVESTMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, chemical drugs are mostly used to treat senile dementia, but most of the chemical drugs have side effects and dependence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The present invention also provides a preparation method of the pharmaceutical composition described in the above technical scheme, comprising the following steps:

[0027] (1) Carry out the first decoction after mixing the ginseng and ginkgo leaves described in the above-mentioned technical scheme with water to obtain the first decoction liquid and the first medicinal residues, the quality of the water being the total mass of ginseng and ginkgo leaves 6 to 10 times; the time for the first decoction is 1 to 3 hours;

[0028] (2) Mix the first medicinal residues obtained in the step (1) with water and decoct for the second time to obtain the second decoction liquid and the second medicinal residues. The quality of the water is the total amount of the first medicinal residues. 4 to 7 times the mass; the second decocting time is 0.5 to 2 hours;

[0029] (3) mixing the first decoction obtained in the step (1) with the second decoction obtained in the step (2) to obtain a w...

Embodiment 1

[0057] 500g ginseng, 1500g ginkgo leaves, add 14000g water, decoct for 2 hours, filter, continue to add 5 times the amount of water to the residue, decoct for 1 hour, combine two decoctions, concentrate under reduced pressure to a density of 1.08-1.12g / m 3 Extract (35°C), add ethanol to adjust to 70% alcohol content, stir thoroughly for 30 minutes, centrifuge at 3000prm for 10 minutes, and take the supernatant. Ethanol is recovered under reduced pressure and concentrated to a density of 1.06-1.08g / m 3 extract (35° C.) to obtain a pharmaceutical composition. Wherein, the quality of the pharmaceutical composition is 196g, the content of the index component ginsenoside Rg1 is 7.58 mg / g, and the total content of ginsenoside is 1485.68 mg / g.

[0058] Mix 196g of the pharmaceutical composition with 150g of starch, 40g of dextrin, and 20g of micropowdered silica gel to make a soft material. After conventional wet granulation and drying, 5g of magnesium stearate is added, pressed int...

Embodiment 2

[0060] 400g ginseng, 1600g ginkgo leaves, add 14000g water, decoct for 2 hours, filter, continue to add 5 times the amount of water to the residue, decoct for 1 hour, combine two decoctions, concentrate under reduced pressure to a density of 1.08-1.12g / m 3 Extract (35°C), add ethanol to adjust to 70% alcohol content, stir thoroughly for 30 minutes, centrifuge at 3000prm for 10 minutes, and take the supernatant. Ethanol is recovered under reduced pressure and concentrated to a density of 1.06-1.08g / m 3 extract (35° C.) to obtain a pharmaceutical composition.

[0061] Mix 196g of the pharmaceutical composition with 150g of starch, 40g of dextrin, and 20g of micropowdered silica gel to make soft materials, adopt conventional wet granulation, and after drying, add 5g of magnesium stearate and fill 400 capsules to obtain capsules. The index component content in the capsule is 2.9mg / capsule.

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Abstract

The invention provides a pharmaceutical composition for improving memory decline and alleviating senile dementia and a preparation method thereof, belonging to the technical field of traditional Chinese medicine, wherein the pharmaceutical composition comprises ginseng radix and ginkgo biloba leaf, and the weight ratio of human participants in ginkgo biloba leaf is 1: 1 to 9. The pharmaceutical composition provided by the invention can be used for improving memory and alleviating Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for improving memory loss and alleviating senile dementia and a preparation method thereof. Background technique [0002] Senile dementia can be divided into Alzheimer's disease, vascular dementia and mixed dementia. Alzheimer's disease is a complex disease characterized by advanced cognitive dysfunction, with senile plaques, neurofibrillary tangles and neuronal loss as the main pathological changes. Due to the long course of senile dementia, multiple pathogenic factors, complex pathological mechanisms, crossover and mutual influence, the etiology is still unknown. Alzheimer's is a relatively common disease, and if Alzheimer's is not treated effectively, it will develop very quickly. In the prior art, chemical drugs are mostly used to treat senile dementia, but there are many side effects and dependence in chemical d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P25/28
CPCA61K36/16A61K36/258A61K2236/331A61K2236/39A61K2236/53A61P25/28A61K2300/00
Inventor 程雪翔
Owner BEIJING CHENGYI INVESTMENT CO LTD
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