Application of quercetin to preparation of medicament for treating endometriosis

A technology of endometrium and quercetin, applied in the application field of medicine, can solve the problems such as no report on the application of quercetin, and achieve the effect of remarkable therapeutic effect, high safety and better curative effect

Inactive Publication Date: 2019-01-22
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But there is no report about the application of quercetin of the present invention in the preparation of medicines for the treatment of endometriosis

Method used

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  • Application of quercetin to preparation of medicament for treating endometriosis
  • Application of quercetin to preparation of medicament for treating endometriosis
  • Application of quercetin to preparation of medicament for treating endometriosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 quercetin performance test

[0032] 1 material

[0033] 1.1 Experimental animals

[0034] 30 BALB / c female mice, 6 weeks old, body weight 18-20g. Purchased from Shanghai Jiesijie Experimental Animal Co., Ltd. Breeding and experiments were performed in the experimental animal room of the Research Institute of Obstetrics and Gynecology Hospital of Fudan University.

[0035] 1.2 Experimental reagents

[0036] Quercetin was purchased from Alexis Corporation, USA, batch number L21600, with a content of 96.6%; it was in the form of yellow powder and stored at room temperature. Quercetin is a polyphenolic bioflavonoid extracted from Pollen.

[0037] 2 Experimental methods

[0038] In this embodiment, first 30 female mice were divided into control group, quercetin low-dose group, 25 mg / kg and quercetin high-dose group HTMP, 100 mg / kg according to the random number table method. In the dose group, the EMs mouse model was established by intraperitoneal injecti...

Embodiment 2

[0059] Embodiment 2 clinical trial (1)

[0060] 1 information

[0061] 1.1 General information

[0062] Select 50 patients who visited the hospital from February 2015 to June 2017, and use the random number table method to divide them into two groups, namely the treatment group and the control group, with 25 patients in each group. There was no significant difference in age, duration of disease, etc., and the balance between groups was good and comparable.

[0063] 1.2 Diagnostic criteria

[0064] According to the standards stipulated by the third academic meeting of the Obstetrics and Gynecology Professional Committee of the Chinese Association of Integrative Medicine and the "Guiding Principles for Clinical Research of New Chinese Medicines for the Treatment of EM", the following diagnostic criteria are drawn up:

[0065] ① Progressive dysmenorrhea;

[0066] ②Low abdomen and lumbosacral swelling during menstruation, gradually aggravated;

[0067] ③Periodic anal pain;

...

Embodiment 3

[0100] Embodiment 3 clinical trials (two)

[0101] This example studies the effects of quercetin on the proliferation, cell cycle, and transcriptome sequencing of ectopic endometrial stromal cells, and further reveals the target and internal effects of quercetin on ectopic endometrial stromal cells mechanism.

[0102] 1 information

[0103] 1.1 General information

[0104] After passing the approval of the Ethics Committee of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine and the informed consent of patients, 6 specimens were collected from December 2016 to December 2017 at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine. All were diagnosed as ovarian endometrioid cysts by laparoscopy and pathology. The patients were 18-50 years old, had regular menstrual cycles, were not menopausal, and had no h...

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Abstract

The invention relates to application of quercetin to preparation of a medicament for treating endometriosis. Quercetin can inhibit proliferation of ectopic endometrial stromal cells, and the growth inhibition effect of ectopic endometrial stromal cells involves expression changes of a plurality of genes, wherein the expression changes mainly comprise biological processes related to cell cycle regulating factors, growth factors, cell factors and the like. By studying the effects of quercetin on uterus ectopic endometrial stromal cell proliferation, cell cycle and transcriptome sequencing, the action target and intrinsic mechanism of quercetin on ectopic endometrial stromal cells are further revealed. Quercetin is safer than provera and nemestran, and can be used in clinical practice with good application prospects.

Description

technical field [0001] The invention relates to the technical field of new applications of quercetin, a monomer of traditional Chinese medicine, in particular to the application of quercetin in the preparation of medicines for treating endometriosis. Background technique [0002] Endometriosis is the appearance of functional endometrium outside the inner wall of the uterine cavity. It causes secondary dysmenorrhea, infertility, chronic pelvic pain and other symptoms that seriously affect the quality of life of patients. Although endometriosis is a benign gynecological disease, it is aggressive, extensively planted, and prone to recurrence, which is very similar to malignant tumors. Endometriosis is a common and frequently-occurring disease among women of childbearing age, with an incidence rate as high as 15%, and the incidence rate is increasing year by year. Although endometriosis has been discovered for more than 100 years, and the pathogenesis of endometriosis has been...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P15/00
CPCA61K31/352A61P15/00
Inventor 张婷婷曹阳孙兆贵庄梦斐牛亚南杨英
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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