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Use of coumaric acid in preparing medicine for treating human acute lymphoblastic leukemia

A technology of acute lymphocytes and p-coumaric acid, which is applied in the field of medicine to achieve the effect of high toxicity and side effects, low price and deepening death

Active Publication Date: 2019-01-25
黄嘉若 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drugs for acute lymphoblastic leukemia are mainly chemotherapy drugs, which are used in conjunction with chemotherapy, and there is no good drug that works alone

Method used

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  • Use of coumaric acid in preparing medicine for treating human acute lymphoblastic leukemia

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Experimental program
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Embodiment 1

[0027] The cytotoxicity of p-coumaric acid against malignant tumor cell lines was determined using a CCK8 kit (Dojindo, Kumamoto, Japan). In summary, cells were aliquoted to fill a 96-well plate, each well containing 5 × 10 4 For each malignant tumor cell, 100 uL of culture medium was used to increase nutrients, and a certain amount of p-coumaric acid was dropped into it for observation for 48 hours. After adding 10 μL / well CCK-8 reagent, continue to observe in the incubator for 2 hours. Finally, the absorption was observed at 450 nm using a microwell reader (ELX800, Bio TEK, USA). All experiments were repeated three times with the same experimental material in triplicate. For each cell line, the value of the maximum half-inhibitory concentration IC50 is calculated using GraphPad Prism 5 software as follows:

[0028] IC50 value of p-coumaric acid for malignant cell tumor

[0029]

[0030] It can be seen from the experimental results that p-coumaric acid has a certain in...

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Abstract

The invention belongs to the technical field of medicine, in particular to the use of coumaric acid in preparing a medicine for treating human acute lymphoblastic leukemia, which has the advantages oflow toxicity, small side effect, high selectivity, low price and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of p-coumaric acid in preparing a medicine for treating human acute lymphoblastic leukemia. Background technique [0002] The chemical name of p-coumalic acid is p-hydroxycinnamic acid, which is mainly distributed in the stems of gramineous plants. Hydroxycinnamic acid forms dimers through oxidative cross-linking reaction or participates in the synthesis reaction of lignin, so that the plant cell wall is in a cross-linked state. This cross-linking is important for maintaining the integrity of plant cell walls and protecting cell tissue from breakdown by invading microorganisms. [0003] The main functions of coumaric acid are: [0004] 1) Antioxidant activity, it has good antioxidant activity on coumaric acid, has a strong scavenging effect on hydrogen peroxide, superoxide radicals, light free radicals, and peroxynitroso, and has a quenching effect on singl...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P35/02
CPCA61K31/192A61P35/02
Inventor 黄嘉若戴小天石林虎
Owner 黄嘉若
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