Use of coumaric acid in preparing medicine for treating human acute lymphoblastic leukemia

A technology of acute lymphocytes and p-coumaric acid, which is applied in the field of medicine to achieve the effect of high toxicity and side effects, low price and deepening death

Active Publication Date: 2019-01-25
黄嘉若 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drugs for acute lymphoblastic leukemia are mainly chemotherapy drugs, whic

Method used

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  • Use of coumaric acid in preparing medicine for treating human acute lymphoblastic leukemia

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[0026] Example 1

[0027] A CCK8 kit (Dojindo, Kumamoto, Japan) was used to determine the cytotoxicity of coumaric acid to malignant tumor cell lines. In summary, the cells are divided equally to fill a 96-well plate, and each well contains 5×10 4 For a malignant tumor cell, use 100uL culture medium to increase the nutrients, and drop a definite amount of p-coumaric acid for 48 hours. Add 10μL / well of CCK-8 reagent and continue to observe for 2 hours in the incubator. Finally, use a microwell reading device (ELX800, Bio TEK, USA) to observe the absorption at 450nm. All experiments were repeated three times after dividing the same experimental materials into three equal parts. The IC50 value of the maximum half-inhibitory concentration of each cell line is calculated using GraphPad Prism 5 software as follows:

[0028] IC50 value of coumaric acid for malignant cell tumor

[0029]

[0030] It can be seen from the experimental results that coumaric acid has a certain inhibitory effe...

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Abstract

The invention belongs to the technical field of medicine, in particular to the use of coumaric acid in preparing a medicine for treating human acute lymphoblastic leukemia, which has the advantages oflow toxicity, small side effect, high selectivity, low price and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of p-coumaric acid in preparing a medicine for treating human acute lymphoblastic leukemia. Background technique [0002] The chemical name of p-coumalic acid is p-hydroxycinnamic acid, which is mainly distributed in the stems of gramineous plants. Hydroxycinnamic acid forms dimers through oxidative cross-linking reaction or participates in the synthesis reaction of lignin, so that the plant cell wall is in a cross-linked state. This cross-linking is important for maintaining the integrity of plant cell walls and protecting cell tissue from breakdown by invading microorganisms. [0003] The main functions of coumaric acid are: [0004] 1) Antioxidant activity, it has good antioxidant activity on coumaric acid, has a strong scavenging effect on hydrogen peroxide, superoxide radicals, light free radicals, and peroxynitroso, and has a quenching effect on singl...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P35/02
CPCA61K31/192A61P35/02
Inventor 黄嘉若戴小天石林虎
Owner 黄嘉若
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