In-vitro controlled release drug and preparation method thereof

A technology for controlled release of drugs and drugs, applied in the field of infrared laser controlled release of drugs in vitro, can solve the problems of poor target organ accumulation ability, unsatisfactory treatment effect, poor targeting, etc., achieve good biocompatibility, reduce Toxic side effects, the effect of high packet load rate

Inactive Publication Date: 2019-02-22
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the drugs currently on the market have poor targeting and poor accumulation capacity in target organs, which makes the therapeutic effect unsatisfactory.

Method used

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  • In-vitro controlled release drug and preparation method thereof
  • In-vitro controlled release drug and preparation method thereof
  • In-vitro controlled release drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0032] Such as figure 1 Shown, the specific preparation process of infrared laser in vitro controlled release medicine of the present invention is as follows:

[0033] 1. Erythrocytes carry target drugs

[0034] 1.1 Red blood cell collection

[0035] Fresh blood was collected from SD rat hearts and collected into anticoagulant tubes. Centrifuge at 1200rpm for 10 minutes, wash three times with PBS-7.4, and remove cells other than red blood cells. A 50% v / v cell suspension was prepared in PBS-7.4 and stored until use.

[0036] 1.2 Erythrocyte hypotonicity-resealing method to entrap target drug

[0037] Dissolve the target drug in PBS, pH to 7.2-7.4, DOX is used in this example, and the concentration of the prepared solution is 1 mg / mL. Insulin entrapment in erythrocytes was performed using the hypotonic-reseal method. The process is as follows:

[0038] (1) Hyp...

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PUM

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Abstract

The invention discloses an in-vitro controlled release drug. Red blood cells are used as carriers of the in-vitro controlled release drug, and a target drug and an infrared fluorescent dye are loadedin the red blood cells. By loading the drug in the red blood cells and modifying a photoresponse substance in the red blood cells, after intravenous administration, the targeted release of the targetdrug is realized through the irradiation of laser (808nm) in vitro. The targeted release drug can improve the targeting efficiency of the drug and reduces the blood clearance rate and the poison effect and the like.

Description

technical field [0001] The invention relates to an in vitro controlled release drug targeted release technology, in particular to an infrared laser controlled release drug in vitro. Background technique [0002] Chemotherapy has become an important way to treat human diseases. However, most of the drugs currently on the market have poor targeting and poor accumulation in target organs, which makes the therapeutic effect unsatisfactory. How to efficiently deliver therapeutic drugs to target organs, increase the drug concentration in the treatment site, and reduce its concentration in normal tissues has become a research hotspot in the field of pharmaceuticals. Contents of the invention [0003] The object of the present invention is to solve the defects existing in the prior art, and provide a system capable of effectively controlling drug targeted release in vitro. [0004] In order to achieve the above purpose, the present invention provides an in vitro controlled relea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/46A61K31/704A61K49/00A61P35/00
CPCA61K31/704A61K47/46A61K49/0034A61P35/00
Inventor 李浩明韩笑金国华施金洪秦建兵
Owner NANTONG UNIVERSITY
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