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Application of germacrone in preparation of medicines for preventing and treating psoriasis

A technology for gemmanone and psoriasis, which is applied in the field of pharmaceutical products and can solve problems such as the absence of gemmanone to treat psoriasis and the like

Active Publication Date: 2019-03-12
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no report on the use of gemmazone in the treatment of psoriasis in the literature

Method used

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  • Application of germacrone in preparation of medicines for preventing and treating psoriasis
  • Application of germacrone in preparation of medicines for preventing and treating psoriasis
  • Application of germacrone in preparation of medicines for preventing and treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0040] Example 1: (Gel)

[0041] Take 1000mg of gemmaketone, add 10mL of soybean oil to dissolve, add to 10g of carbomer soaked in 500mL of water and mix evenly, add distilled water to 1000g, stir well, add triethanolamine to adjust the pH value to about 10, and obtain 0.1% gemma Ketone gel.

example 2

[0042] Example 2: (ointment)

[0043] Take 1000mg of cichoric acid, add 1000mg of citric acid, 500mg of sodium citrate, 1800mg of sodium chloride, add 1000ml of water for injection, stir to dissolve, sterilize and filter, fill and seal, and sterilize by flowing steam at 100°C for 15 minutes. Prepare each 2mg / 2ml injection for injection use.

[0044] Take 1000mg of gemacerone, add 120g of stearic acid, 35g of glyceryl monostearate, 60g of liquid paraffin, 10g of vaseline, and 50g of lanolin, put it in a container, and put it in a water bath to 75°C, and stir well; add distilled water to 725g, and put it in a water bath Stir well at 75°C, slowly pour into stearic acid and other oil phases, stir well until emulsification is complete, and let cool to obtain 0.1% gemazone ointment.

example 3

[0045] Example 3: (capsules)

[0046] Take 500 mg of gemacerone, 4000 mg of microcrystalline cellulose, 500 mg of sodium carboxymethyl starch, 400 mg of sodium lauryl sulfate and other auxiliary materials, fully mix them, carry out dry granulation by roller compaction, and then mix them with an appropriate amount of magnesium stearate. Fill into 3# hollow capsules, and make capsules with a specification of 10 mg / grain for oral use.

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Abstract

The invention relates to application of germacrone in preparation of medicines for preventing and treating psoriasis. The application is characterized in that the medicine consists of germacrone and amedically acceptable auxiliary material, wherein the content of the germacrone in the medicine is 0.1% to 50% in percentage by mass. The medicine has the function of resisting psoriasis, and can be used for preventing and treating the psoriasis.

Description

technical field [0001] The invention relates to pharmaceutical products containing organic active ingredients, in particular to medicines containing sesquiterpene compounds. Background technique [0002] Psoriasis is a common chronic skin disease, easy to relapse, stubborn and can cause systemic damage. The main histopathological changes are hyperproliferation of keratinocytes, infiltration of inflammatory cells and vascular proliferation in dermal tissue. At present, the population affected by this disease accounts for about 2%-3% of the world's total population, and the incidence rate in European and American countries is relatively high, and it is increasing year by year. Psoriasis is refractory and easy to relapse, requires long-term treatment, takes up a lot of medical resources, and costs a lot. At the same time, psoriasis can easily lead to various complications such as psoriatic arthritis, metabolic syndrome, and malignant tumors, which will bring secondary harm to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P17/06
CPCA61K31/122A61P17/06
Inventor 卢传坚韩凌陈海明张金卫戴振华
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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