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Application of curcumol in preparing medicine for preventing and treating psoriasis

A technology of curcumol and psoriasis, which is applied in the field of pharmaceutical products and can solve the problems of treating psoriasis without curcumol

Inactive Publication Date: 2019-02-15
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no report that curcumol is used for the treatment of psoriasis in the current literature.

Method used

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  • Application of curcumol in preparing medicine for preventing and treating psoriasis
  • Application of curcumol in preparing medicine for preventing and treating psoriasis
  • Application of curcumol in preparing medicine for preventing and treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0039] Example 1: (Gel)

[0040] Take 1000mg of curcumol, add 10mL of soybean oil to dissolve, add 10g of carbomer soaked in 500mL of water and mix evenly, add distilled water to 1000g, add triethanolamine to adjust the pH value to about 10 after stirring well, and obtain 0.1% curcumol coagulation Glue.

example 2

[0041] Example 2: (ointment)

[0042] Take 1000mg of cichoric acid, add 1000mg of citric acid, 500mg of sodium citrate, 1800mg of sodium chloride, add 1000ml of water for injection, stir to dissolve, sterilize and filter, fill and seal, and sterilize by flowing steam at 100°C for 15 minutes. Prepare each 2mg / 2ml injection for injection use.

[0043] Take 1000mg of curcumol, add 120g of stearic acid, 35g of glyceryl monostearate, 60g of liquid paraffin, 10g of vaseline, and 50g of lanolin, put it in a container, put it in a water bath to 75°C, and stir well; add distilled water to 725g, and take a water bath to Stir well at 75°C, slowly pour into stearic acid and other oil phases, stir well until the emulsification is complete, and let cool to obtain 0.1% curcumol ointment.

example 3

[0044] Example 3: (capsules)

[0045]Take 500mg of curcumol, 4000mg of microcrystalline cellulose, 500mg of sodium carboxymethyl starch, 400mg of sodium lauryl sulfate and other auxiliary materials, mix well, use the roller compaction method for dry granulation, and then mix with an appropriate amount of magnesium stearate, fill Enter 3# empty capsules, make the capsule that specification is 10mg / grain for oral use.

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PUM

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Abstract

The invention relates to an application of curcumol in preparing a medicine for preventing and treating psoriasis. The medicine in the application consists of curcumol and medically acceptable auxiliary materials, wherein the mass percentage of the curcumol used in the medicine is 0.1-50%. The medicine provided by the invention has an effect of resisting psoriasis and can be used for preventing and treating psoriasis.

Description

technical field [0001] The invention relates to pharmaceutical products containing organic active ingredients, in particular to medicines containing sesquiterpene compounds. Background technique [0002] Psoriasis is a common autoimmune skin disease, easy to relapse, long disease cycle, and can cause complications, such as psoriatic arthritis, inflammatory bowel disease, tumors, metabolic syndrome, etc. At present, the population affected by this disease is about 15 million, accounting for 2%-3% of the world's total population, and it is increasing year by year. Choose according to the severity of the patient's condition, mainly including local treatment, systemic treatment and phototherapy. Western medicine shows better effects in the short term in the treatment of psoriasis, but long-term use also produces some side effects. As the first-line topical treatment, vitamin D derivatives have definite curative effect, but long-term use is likely to cause metabolic disorders. ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P17/06
CPCA61K31/352A61P17/06
Inventor 卢传坚韩凌陈海明张金卫戴振华
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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