A kind of pharmaceutical composition for suppressing tumor cells

Abstract

The invention provides a pharmaceutical composition for inhibiting tumor cells, which comprises vinorelbine, cisplatin and pachymane. The Poria cocos polysaccharide combined with vinorelbine + cisplatin can significantly improve the anti-tumor effect of tumor-bearing mice, and the average tumor volume and tumor inhibition rate are significantly different from those of the vinorelbine + cisplatin group (P<0.05); And the curative effect of the combined drug q>1, it shows that the polysaccharide can enhance the therapeutic effect of vinorelbine combined with cisplatin; the combination of polysaccharide with vinorelbine and cisplatin can significantly improve the side effects such as severe weight loss and low immunity caused by chemotherapy , the difference was statistically significant (P<0.05); pachymansin could increase the serum levels of IL-2 and TNF-α in the tumor-bearing mice inhibited by chemotherapy drugs, and the difference in IL-2 was significant. In conclusion, Poria cocos polysaccharide can help enhance the therapeutic effect of vinorelbine and cisplatin combined therapy on lung cancer, and significantly reduce the side effects caused by radiotherapy and chemotherapy.

Description

technical field [0001] The invention belongs to the field of tumor medicine, and in particular relates to a pharmaceutical composition for inhibiting tumor cells. Background technique [0002] Non-small-cell lung cancer (NSCLC) is the most common lung malignancy in the world, and its morbidity and mortality rank first among all malignancies. Studies have reported that the incidence and mortality of lung cancer in my country are increasing year by year, which is a major public health problem in our country. Since most lung cancer patients are diagnosed at an advanced stage and have lost the opportunity for surgery, chemotherapy is the main treatment in clinical practice, among which vinorelbine combined with cisplatin is the main first-line treatment drug. [0003] The chemical name of vinorelbine is 3′,4′-didehydro-4′-deoxy-8′-norvinblastine, and its molecular formula is C 45 h 54 N 4 o 8 , a semi-synthetic vinca alkaloid with broad-spectrum antitumor activity and low t...

AI Technical Summary

Problems solved by technology

[0005] When vinorelbine is used in combination with cisplatin, there are side effects such as immunosuppression, gastrointestinal system toxicity and bone marrow suppression, and drug resistance is easy to develop, which makes the patient's tolerance to chemotherapy significantly reduced

Images