Immune preparation capable of improving immune effect of foot-and-mouth disease vaccine for tibetan sheep and extraction method of immune preparation

A technology of foot-and-mouth disease vaccine and extraction method, which is applied in the field of immune preparation and extraction to enhance the immune effect of Tibetan sheep foot-and-mouth disease vaccine, can solve the problems of the gap between the immune effect and the expected effect, achieve obvious weight gain, reduce immunosuppression, and have no antigenicity Effect

Inactive Publication Date: 2019-03-19
QINGHAI UNIVERSITY
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Problems solved by technology

New vaccines such as genetic engineering vaccines, DNA vaccines, and live vector vaccines have attracted much attention, but there is still a certain gap between the immune effect and the expected effect

Method used

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  • Immune preparation capable of improving immune effect of foot-and-mouth disease vaccine for tibetan sheep and extraction method of immune preparation
  • Immune preparation capable of improving immune effect of foot-and-mouth disease vaccine for tibetan sheep and extraction method of immune preparation
  • Immune preparation capable of improving immune effect of foot-and-mouth disease vaccine for tibetan sheep and extraction method of immune preparation

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Embodiment Construction

[0018] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0019] The invention provides an immune preparation for enhancing the immune effect of a Tibetan sheep foot-and-mouth disease vaccine, which is derived from yak, a unique species on the Qinghai-Tibet Plateau.

[0020] A kind of extraction method of the immune preparation of strengthening the immune effect of Tibetan sheep foot-and-mouth disease vaccine of the present invention is:

[0021] Select fresh placentas from healthy yaks after normal delivery, store them frozen, and then thaw them at room temperature. After washing the blood, wash the placenta with normal saline, remove blood vessels and fascia, cut them into piece...

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Abstract

The invention relates to a biological immunological enhancement preparation and in particular relates to an immune preparation capable of improving the immune effect of a foot-and-mouth disease vaccine for tibetan sheep and an extraction method of the immune preparation. The immune preparation is cooperated with the vaccine to generate an effect and is capable of increasing the immune level of anorganism, promoting the generation of an antibody, shortening the immune response period of the organism and prolonging the peak period of the antibody, so that the vaccine can generate a better effect. The extraction method of the immune preparation capable of improving the immune effect of the foot-and-mouth disease vaccine for tibetan sheep comprises the following steps: selecting a normally-delivered fresh placenta of a healthy yak, carrying out cryostorage, then, carrying out normal-temperature unfreezing, cleaning and shearing, carrying out tissue homogenization and repeated freezing andthawing, and then, carrying out freeze centrifugation, microfiltration and ultrafiltration to prepare a finished product.

Description

technical field [0001] The invention relates to a biological immune enhancement preparation, in particular to an immune preparation and an extraction method for enhancing the immune effect of Tibetan sheep foot-and-mouth disease vaccine. Background technique [0002] Foot-and-mouth disease is commonly known as "mouth sores and hoof rash". As early as 1544, Hieronymus and Fractastorius discovered the disease in Italy; in 1893, a disease similar to foot-and-mouth disease was prevalent in Xishuangbanna, Yunnan; in 1902, a large epidemic of foot-and-mouth disease occurred in Jiuquan, Gansu , and later became popular in Qinghai, Xinjiang, Jiangsu, Hebei and other places, causing serious losses. The pathogen of foot-and-mouth disease vaccine is foot-and-mouth disease virus (Foot-and-mouth disease virus), which belongs to the representative species of foot-and-mouth disease virus genus (Aphthovirus) of picornaviridae (Picornnviridac). Foot-and-mouth disease virus has multiple type...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P37/04
CPCA61K39/39A61K2039/55588A61P37/04
Inventor 宁鹏文英常建军康明张勤文
Owner QINGHAI UNIVERSITY
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