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Rosa roxburghii triterpenoid extract and application thereof

A technology of extract and Rosa roxburghii, which is applied in the field of medicine, can solve the problems of not discussing the therapeutic effect of Rosa roxburghii extract on alcoholic liver disease, and not involving the application of Rosa roxburghii triterpene extract, so as to achieve product deformability and market acceptance wide, reduce liver tissue fat accumulation, simple preparation process

Inactive Publication Date: 2019-04-16
阎永平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yet above-mentioned invention does not relate to the application of Rosa roxburghii triterpene extract
At the same time, the therapeutic effect of Rosa roxburghii extract on alcoholic liver disease has not been explored.

Method used

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  • Rosa roxburghii triterpenoid extract and application thereof
  • Rosa roxburghii triterpenoid extract and application thereof
  • Rosa roxburghii triterpenoid extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Various roxburghii extracts are used for the prevention and treatment of alcoholic liver disease caused by the NIAAA model

[0052] 1. Instruments and materials

[0053] Main instruments: electronic balance (Shanghai METTLER TOLEDO); Buchi rotary evaporator (Switzerland Buchi company); electric heating mantle (Tianjin Tioste Instrument Co., Ltd.); traditional Chinese medicine pulverizer (Shanghai Dianjiu Chinese Medicine Machinery Manufacturing Co., Ltd.); Full-wavelength microplate reader (Thermo Company, USA); centrifuge (Eppendorf Company, Germany); low-speed desktop centrifuge (Keda Zhongjia); DZF-6020 vacuum drying oven (Shanghai Jinghong).

[0054] Drugs and reagents: liquid feed (Lieber-DeCarli diet ad libitum) and liquid alcohol feed (Nantong Trofee Feed Technology Co., Ltd.); ethanol and ethyl acetate (Burdick&Jackson); prickly pear dried fruit (Guangrentang Herbs Store, Haozhou City) ; ALT, AST, TG detection kits (Nanjing Jiancheng Institute of Bioe...

Embodiment 2

[0082] Example 2: Preparation of tablets and capsules comprising 8-99% prickly pear triterpene extract:

[0083] Get the dry powder of Rosa roxburghii triterpene extract, pass through a 60-100 mesh sieve for later use. (1) Add one or several kinds of excipients commonly used in tablets; compress into tablets by a tablet machine. Each tablet contains 82.5-330 mg of Rosa roxburghii triterpene extract, and the weight of the tablet can be adjusted according to the drug loading.

[0084] (2) Add one or several kinds of auxiliary materials commonly used in capsules, granulate, granulate, and pack into capsules. Each capsule contains 82.5-330mg of triterpene extract, and the weight of the capsule can be adjusted according to the drug loading. See Table 5. Suggested dosage: Take 6 capsules per day, 2 capsules per meal, 82.5-165mg of Rosa roxburghii triterpene extract per capsule; daily intake is 495-990mg. Or take 3 capsules per day, 1 capsule / meal, 165-330mg prickly pear triterpe...

Embodiment 3

[0101] Embodiment 3: preparation comprises the granule and suspension of 2.475-99% prickly pear triterpene extract:

[0102] Taking 10g / bag as an example, the specific dosage form specification (weight / bag) can be adjusted according to the drug loading. Get the dry powder of Rosa roxburghii triterpene extract, pass through a 60-100 mesh sieve for later use. Take 247.5-990g of the above-mentioned dry powder, arbitrarily proportioning 9010-9752.5g of auxiliary materials; make the total weight 10000g. Add a small amount of solvent and mix well to make granules, dry, pack one bag per 10g; 1000 bags in total. The excipients include, but are not limited to: sweeteners, powdered sugar, dextrin, β-cyclodextrin, and effervescent disintegrants. Each bag of the prepared Rosa roxburghii triterpene extract granule contains 2.475-99% of the Rosa roxburghii triterpene extract; recommended dose: take 1-2 bags per day, and the daily intake is 495-990 mg. See Table 6 - Take Granules and Susp...

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Abstract

The invention discloses an application of a rosa roxburghii triterpenoid extract in preparation of drugs, health-care products and health-care food for preventing and treating alcoholic liver disease.Provided are the drugs and health-care products for preventing and treating alcoholic liver disease, wherein the drugs and health-care products comprise 2-99% of the rosa roxburghii triterpenoid extract, and the rosa roxburghii triterpenoid extract is used as an active ingredient. The invention also provides health-care drinks suitable for patients with alcoholic liver disease, wherein the health-care drinks comprise 0.05-0.7% of the rosa roxburghii triterpenoid extract. The health-care drinks comprise alcoholic drinks, fruit-flavored beer drinks, grape wine drinks and the like. Through implementation of a most recognized model of alcoholic liver disease in mice, the rosa roxburghii triterpenoid extract is found out to alleviate the liver pathological changes induced by alcohol in different extents; liver enlargement, weight gain and fat accumulation degree are significantly improved; biochemical and pathological indicators are decreased; the level of triglycerides in liver is significantly reduced. Therefore, the rosa roxburghii triterpenoid extract can prevent and treat alcoholic liver disease, can be used as drugs separately or in combination, and is used for developing corresponding drugs, health-care products or health-care food.

Description

technical field [0001] The invention belongs to the field of medicine. It relates to a prickly pear triterpene extract and its application. More specifically, it relates to the extract of Rosa roxburghii triterpene and its application in the preparation of drugs and / or health care products for the prevention and treatment of alcoholic liver disease. Rosa roxburghii triterpene extract can be obtained by different processes. Background technique [0002] Alcoholic liver disease (ALD) is liver damage caused by long-term heavy drinking. At present, it has become the second leading cause of liver injury after viral hepatitis in my country. Epidemiological data in 2000 showed that in my country, the population suffering from alcoholic liver disease accounted for about 5% of the total adult population; the data is still rising. With the deepening of research, it is found that its disease spectrum includes simple fatty liver (Alcoholic fatty liver, AFL) and some serious liver da...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23L2/52C12C5/02C12G3/04C12G1/00A61K36/738A61P1/16
CPCA23L2/52A23V2002/00A61K36/738A23L33/105C12C5/02C12G1/00C12G3/04C12G2200/21A23V2200/30A23V2250/21A23V2250/21372A23V2250/21168A23V2250/2116
Inventor 胡冰芳
Owner 阎永平
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