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Novel application of circular RNA hsa_circ_0012152

A new use, circular technology, applied in the direction of DNA / RNA fragments, recombinant DNA technology, microbial measurement / inspection, etc., can solve the problems of unknown biological effects and clinical significance

Pending Publication Date: 2019-04-16
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently, the biological role and clinical significance of hsa_circ_0012152 in pediatric AML are completely unknown

Method used

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  • Novel application of circular RNA hsa_circ_0012152
  • Novel application of circular RNA hsa_circ_0012152
  • Novel application of circular RNA hsa_circ_0012152

Examples

Experimental program
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Embodiment Construction

[0018] Embodiments of the present invention are described below through specific examples.

[0019] The technologies involved in the present invention are conventional technical means of molecular cloning, and the enzymes, primers, reagents and reaction conditions involved in them can be reasonably selected according to the experience of those skilled in the art unless otherwise specified, and the reagent consumables involved belong to Commercially available common products, detection means and instruments involved therein are also well known and mastered by those skilled in the art.

[0020] 1. Sequencing verification of the circularization site of the circular RNA hsa_circ_0012152 gene

[0021] 1. Cell collection and pretreatment

[0022] 1ml of umbilical cord venous blood was collected from 2 pregnant women who gave birth in Guangzhou Women and Children's Medical Center, and all participants signed informed consent. Mononuclear cells were collected by density gradient cen...

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Abstract

The invention discloses application of circular RNA hsa_circ_0012152 as a therapeutic target in the preparation of a medicament for treating acute myeloid leukemia in children.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a new application of circular RNA hsa_circ_0012152. Background technique [0002] Acute leukemia is the most common malignancy in children, accounting for approximately 35% of malignancies during this period. Although childhood acute myeloid leukemia (acute myeloid leukemia, AML) only accounts for 20% of acute leukemia, but its death toll accounts for more than 50% of childhood acute leukemia. With the application of combination chemotherapy, optimized risk stratification and hematopoietic stem cell transplantation technology, the survival rate of children with AML has been greatly improved, but the prognosis is still poor, and the recurrence rate is as high as 30%. This not only seriously endangers the physical and mental health of the children, but also brings serious economic and psychological burdens to the families of the patients. Therefore, it is of great...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 刘晓丹蔡蔓斯徐令
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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