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Aerosol inhalation medicine composition for treating cough and asthma and preparation method thereof

A technology for nebulizing drugs and compositions, applied in the field of medicine

Inactive Publication Date: 2019-04-26
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, it is popular to adopt ultrasonic atomization, which is inhaled from the respiratory tract, so that the drug can directly act on the focus of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of Radix Astragalus Extract

[0048] preparation:

[0049] Take 200g of Astragalus membranaceus, decoct twice with water, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to 1-2g of the original medicinal material per 1ml, and use ethanol precipitation treatment twice, the ethanol content in the two solutions is 75%, put it in cold storage each time, recover ethanol and concentrate it to 10g of the original medicinal material per 1ml, dilute it with water for injection to 0.75-1g of the original medicinal material per 1ml, keep it in cold storage for 14 hours, filter, and concentrate the filtrate to 1ml of the original medicinal material Equivalent to 5-6g of the original medicinal material, let it cool, adjust the pH value to 7.5 with 20% sodium hydroxide solution, boil, add 0.125% activated carbon, boil for 10 minutes, filter while it is hot, add water for injection to make 100ml, filter , and then adjust the pH val...

Embodiment 2

[0050] Example 2 Preparation of atomized composition

[0051] Add 300ug of budesonide, 600ug of terbutaline sulfate, 10mg of ambroxol hydrochloride, 0.5mL of astragalus extract, and 0.5ml of propylene glycol into 10mL of normal saline and mix uniformly to obtain an atomized inhalation solution.

[0052] After nebulizing the obtained nebulized inhalation liquid with an ultrasonic nebulizer, it is directly inhaled into the respiratory system in the form of nebulization.

Embodiment 3

[0053] Example 3 Preparation of atomized composition

[0054] Add 600ug of budesonide, 1200ug of terbutaline sulfate, 15mg of ambroxol hydrochloride, 1mL of astragalus extract, and 0.5ml of propylene glycol into 10mL of normal saline and mix evenly to obtain an atomized inhalation solution.

[0055] After nebulizing the obtained nebulized inhalation liquid with an ultrasonic nebulizer, it is directly inhaled into the respiratory system in the form of nebulization.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and provides an aerosol inhalation medicine composition for treating cough and asthma. The aerosol inhalation medicine composition for treating cough and asthma is prepared from 300 to 600ug of budesonide, 600 to 1200ug of terbutaline sulfate, 10 to 15mg of ambroxol hydrochloride, 0.5 to 1mL of radix astragali extracts, 0.5ml of propanedioland 10ml of normal saline. The invention also provides a preparation method of the aerosol inhalation medicine composition.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an atomized medicinal composition for preparing cough and asthma. Background technique [0002] Cough Type Asthma (Cough Type Asthma), also known as Cough Variant Asthma (Cough variant Asthma, CVA), was first reported by Gluser in 1972 and named as Cough Variant Asthma, which refers to chronic cough as the main or only clinical manifestation. A specific type of asthma. GINA (Global Initiative for Asthma Prevention) clearly believes that cough variant asthma is a form of asthma, and its pathophysiological changes are the same as asthma, which are persistent airway inflammation and airway hyperresponsiveness. At the onset of bronchial asthma, 5% to 6% have persistent cough as the main symptom, which mostly occurs at night or in the early morning. It is often an irritating cough and is often misdiagnosed as bronchitis at this time. The age of onset is higher than that...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/72A61K9/12A61K47/10A61P11/06A61P11/14A61K31/58A61K31/137
CPCA61K36/481A61K9/0043A61K9/0078A61K9/12A61K31/137A61K31/58A61K47/10A61P11/06A61P11/14A61K2300/00
Inventor 张新颖聂翠丽
Owner SHANDONG PROVINCIAL HOSPITAL
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