A kind of oral instant film containing rizatriptan benzoate and preparation method thereof

Abstract

The invention belongs to the technical field of medicine, and relates to an oral instant film preparation containing rizatriptan benzoate prepared by an electrospinning process. The oral instant film prescription comprises 1 part of rizatriptan benzoate, 1-300 parts of film-forming material and 0-50 parts of other auxiliary materials. Oral instant film is obtained through electrospinning process. The conditions of electrospinning are: voltage 5-20kV, advancing speed 0.1-10ml / h, receiving distance 5-20cm, temperature 5-60℃, humidity 10-70%. The oral instant film is composed of nano-polymer fibers formed by electrospinning, and the diameter of the nano-polymer fibers is 10-1000nm. The rizatriptan benzoate is uniformly distributed in an amorphous state in the film preparation. The oral instant film containing rizatriptan benzoate protected by the present invention has higher specific surface area and porosity and faster dissolution rate, more rapid onset, higher bioavailability, and can quickly relieve migraine patient suffering.

Description

A kind of oral instant film containing rizatriptan benzoate and preparation method thereof technical field The invention belongs to technical field of medicine, relate to a kind of oral cavity instant film, be specifically related to a kind of containing benzoic acid Oral instant film preparation of zatriptan and preparation method thereof. Background technique Migraine is a kind of chronic disease, clinical manifestation is intense, intermittent headache on one side, which brings great pain to patients. Great pain, but also seriously affect the patient's quality of life. Epidemiological surveys show that the incidence of migraine in my country is 4.2‑ 14.6%, and the incidence in women (18%) is higher than that in men (6%). About 80% of migraine sufferers experience nausea, vomiting or Other symptoms of intestinal disorders in patients, which seriously affect the compliance and effective absorption of oral drugs. Thus, the development takes effect quickly The do...

AI Technical Summary

Problems solved by technology

However, in the process of solvent volatilization, the local drug concentration will continue to rise, which is likely to cause recrystallization of the drug, especially for insoluble drugs, which are more likely to precipitate, resulting in problems such as uneven distribution of the drug in the film

In addition, the heating process is also a severe test for drugs with poor thermal stability.

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