A method for adjusting the culture process of microalgae under nitrogen nutrient stress based on feedback control
A regulation method and feedback control technology, which can be used in material excitation analysis, fluorescence/phosphorescence, etc., to solve the problems of inability to accurately control the degree of microalgae stress and the inability to monitor the degree of stress online.
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Embodiment 1
[0039] A 500mL columnar glass bubbler reactor ( figure 2 ) culture of Nannochloropsis mesophyllum as an example, the reaction conditions are culture temperature 25±2℃, light intensity 140μmol m –2 the s –1 , air CO 2 The ventilation volume is 100mL min –1 , only when the light passes into the CO 2 , CO 2 The amount of inflow is 2% of the air inflow, the light-dark ratio is 14h:10h, and the light time is 8:00-20:00 every day. Seawater culture, using improved F / 2 nutrient salts, the final concentration of each nutrient salt in the mother liquor is (per liter): 75.00g NaNO 3 , 5.00g NaH 2 PO 4 , 3.15g FeCl 3 ·6H 2 O, 4.36 g Na 2 EDTA, 9.80 mg CuSO 4 ·5H 2 O, 6.30 mg Na 2 MoO 4 2H 2 O, 22.00mgZnSO 4 ·7H 2 O, 10.00 mg CoCl 2 ·6H 2 O, 0.18g MnCl 2 4H 2 O, 1.00mg vitamin B12, 0.20g vitamin B1, 1.10mg biotin. The nitrogen nutrient concentration in the system is expressed by the final concentration of nitrogen element.
[0040] In this example, microalgae cell c...
Embodiment 2
[0046] In the present embodiment, the microalgae cell culture of 4 kinds of culture conditions is carried out, except culture condition 4, other 3 kinds of cultures are the same as embodiment 1. Culture condition 4 adopts semi-continuous culture, that is, when the degree of cell stress reaches the set value, it is diluted according to the set dilution rate, and nutrients are added (the specific addition method is the same as that of culture condition 4 in Example 1), and a new culture is started. cycle. Among them, the dilution rate refers to the ratio of the volume of fresh medium added during re-dilution to the total culture volume during semi-continuous culture. Specifically, in the culture condition 4 of this example, the NSI is controlled at 0.73 and the intracellular nitrogen content is 3.73%wt. At this time, the online characterization parameter ΔF / F of the current nitrogen stress degree m ’ with a value of 0.503. Figure 5 is based on ΔF / F m’ Feedback control result...
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