Detection method for treating inflammatory bowel disease through macrophage migration inhibitory factor resistant antibody
A technology for inflammatory bowel disease and migration inhibition, applied in the field of bowel disease detection, can solve the problems of high price of anti-MIF antibodies, no reports on the efficacy of anti-MIF antibodies, and rare reports.
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[0043] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0044] The present invention adopts 5% DSS and BALB / c mice to make the model, successfully establishes the UC mouse model, and performs mouse activity index (ADI) score, colon general and histological score on the mouse.
[0045] The present invention uses DSS to induce the establishment of a rat colitis model, and judges the severity of colitis by observing the clinical characteristics of the animals and the damage of the colon. The levels of MIF, TNF-α, and IL-6 in the serum and colon tissue of animals in the treatment group were analyzed to analyze the role of pro-inflammatory cytokines MIF, TNF-α, and IL-652 in the path...
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