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Medicine with pain relieving and arthritis treating functions prepared from cedrol as raw materials

A technology of cedrol, arthritis, used in the field of medicine to achieve good analgesic and anti-inflammatory effects

Inactive Publication Date: 2019-05-28
孔祥圣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of western medicine are increasingly being paid attention to and evaluated by the international community. At the same time, patients' self-protection awareness of disease treatment is constantly increasing, which makes many pharmaceutical companies increase their investment and speed to develop effective and safe natural medicines.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Example: Effects on Adjuvant Arthritis in Rats

[0024] Methods: 60 SD rats were taken and divided into 5 groups on average according to body weight: (1) 1% TW-80 (vehicle); (2) positive control drug dexamethasone phosphate injection 2.5 mg / kg; (3) α - CE 25 mg / kg; (4) α-CE 50 mg / kg; (5) α-CE 100 mg / kg. All were administered by intragastric administration (ig). Inject 0.1 ml of Freund's complete adjuvant (containing 0.5 mg of BCG) into the right hind paw. Oral administration once 30 minutes before the injection of adjuvant. 18 hours after the injection of the adjuvant, measure the swelling of the right hind paw, observe the preventive effect of CE on early acute inflammation, and then stop the drug; one week later, start intragastric administration, once a day, for 7 consecutive days, and measure once on d15 Observe the preventive effect of CE on secondary lesions for the swelling of the left hind foot, and then stop the drug; start therapeutic administration from d1...

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Abstract

The invention relates to medicine with pain relieving and arthritis treating functions prepared from cedrol as raw materials. The cedrol is cedrol, beta-CE or raceme of cedrol and beta-CE at any proportion; the total effective dosage is 1 to 100 mg / kg / d. The CE is extracted from natural plants with wide resources. A rat foot carrageenan inflammatory method and adjuvant arthritis are used for observing the anti-inflammatory effect of the CE; through the result, the effect that the CE has an obvious inhibition effect on the nonspecific inflammatory reaction due to carrageenin can be shown; meanwhile, the obvious treatment and prevention effects are achieved on the adjuvant arthritis. A tail-flick method is used for observing the pain relieving effect of the CE. Through the result, the effectthat the CE has an obvious pain relieving effect on the rat photothermal stimulation tail part can be discovered. The invention provides raw materials of the anti-inflammatory and paint relieving medicine with the advantages of exact curative effect, safety, convenience and wide sources. The raw materials can be combined with one or more kinds of medically acceptable carriers to be made into a cedrol medicine composition or preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for analgesia and arthritis treatment prepared by using cedrol as a raw material. Background technique [0002] Arthritis is a common chronic disease, which refers to arthritic lesions caused by inflammation, infection, trauma or other factors, and belongs to rheumatology diseases. Its main features are joint swelling, heat, pain, and dysfunction. It is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. The most common types are osteoarthritis and rheumatoid arthritis. According to statistics, half of the people over the age of 50 in my country suffer from osteoarthritis; 90% of the women and 80% of the men over the age of 65 suffer from osteoarthritis. The prevalence of rheumatoid arthritis in my country is 0.34% to 0.36%. According to reports, the life expectancy of patients with severe ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P19/02A61P29/00A61P31/00
Inventor 孔祥圣
Owner 孔祥圣
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