Mesoporous nano zirconia drug-loaded material, its preparation method and sustained and controlled drug release

A technology of nano-zirconia and controlled-release drugs, which is applied in the directions of nano-drugs, pharmaceutical formulations, nano-technology, etc., to achieve the effect of long release time, high biological safety and good uniformity

Active Publication Date: 2022-03-18
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for drugs with negative charges on the surface, drug loading cannot be carried out by conventional vacuum pumping negative pressure.

Method used

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  • Mesoporous nano zirconia drug-loaded material, its preparation method and sustained and controlled drug release
  • Mesoporous nano zirconia drug-loaded material, its preparation method and sustained and controlled drug release
  • Mesoporous nano zirconia drug-loaded material, its preparation method and sustained and controlled drug release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Take 20mg of mesoporous nano-zirconia particles, add 5mL of deionized water and 5mL of absolute ethanol, mix thoroughly, then quickly add 40μL of aminosilane dropwise under magnetic stirring conditions, and magnetically stir overnight;

[0082] Put the mesoporous nano-zirconia particles stirred overnight into a centrifuge tube, centrifuge at a high speed (10000r / min, 10min), discard the supernatant, wash twice with 5mL of absolute ethanol and twice with 5mL of deionized water, and discard Remove the supernatant to obtain the aminated mesoporous nano-zirconia drug-loaded material;

[0083] Take 40mg of arsenic trioxide powder, mix thoroughly with 20mL of deionized water, stir overnight by magnetic force, fully dissolve the drug, and obtain arsenic trioxide solution;

[0084] Mix the above-mentioned arsenic trioxide solution into the above-mentioned aminated mesoporous nano-zirconia particles, under the condition of ultrasonic vibration (ultrasonic power is 50W, ultrasoni...

Embodiment 2

[0087] Take 20mg of mesoporous nano-zirconia particles, add 5mL of deionized water and 5mL of absolute ethanol, mix thoroughly, then quickly add 40μL of aminosilane dropwise under magnetic stirring conditions, and magnetically stir overnight;

[0088] Put the mesoporous nano-zirconia particles stirred overnight into a centrifuge tube, centrifuge at a high speed (10000r / min, 10min), discard the supernatant, wash twice with 5mL of absolute ethanol and twice with 5mL of deionized water, and discard Remove the supernatant to obtain the aminated mesoporous nano-zirconia drug-loaded material;

[0089] Take 40mg of arsenic trioxide powder, mix thoroughly with 20mL of deionized water, stir overnight by magnetic force, fully dissolve the drug, and obtain arsenic trioxide solution;

[0090] Mix the above-mentioned arsenic trioxide solution into the above-mentioned aminated mesoporous nano-zirconia particles, under the condition of ultrasonic vibration (ultrasonic power is 60W, ultrasoni...

Embodiment 3～5

[0093] The method in Examples 3-5 refers to the method in Example 1, the difference is that the amount or type of each substance, centrifugation or ultrasonic conditions, etc. are changed, and the specific condition changes are listed in Table 1.

[0094] Table 1 embodiment 3~5 concrete condition change

[0095]

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Abstract

The invention relates to a drug-loaded material of mesoporous nano zirconia. The surface of the mesoporous nano zirconia is modified with groups with amino groups; group, at least one of an amino-containing alkene group. The drug-loading material has good drug-loading stability and high biological safety. The invention also relates to a preparation method of the mesoporous nanometer zirconium dioxide drug-loading material and its application in slow and controlled drug release. The preparation method of the mesoporous nano-zirconia drug-loading material is simple, efficient, and highly operable. It has successfully constructed a mesoporous nano-zirconia drug-loaded system loaded with negatively charged drug active components, which is a mesoporous nano-zirconia drug-loaded system. Negatively charged drugs with zirconium loading and their own charges bring a new method and idea, and the sustained and controlled release effect of the drug is remarkable.

Description

technical field [0001] The invention relates to the fields of pharmaceutical preparations and drug loading, in particular to a mesoporous nano-zirconia drug-loading material, a preparation method thereof, and sustained-controlled drug release. Background technique [0002] At present, the drug commonly used to load mesoporous zirconia nanoparticles is doxorubicin hydrochloride. Since the charge attached to the surface of doxorubicin hydrochloride is positive, the negatively charged nano-zirconia particles on the surface can attract and mediate. The role of the pore structure, the use of vacuum negative pressure to achieve the effect of drug loading. However, for drugs with negative charges on the surface, drug loading cannot be carried out by conventional vacuum pumping. Therefore, it is of great practical significance to develop suitable mesoporous nano-zirconia particle drug-loading materials and preparation methods for loading negatively charged drugs. [0003] In view ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/52B82Y5/00
Inventor 吴启润徐克
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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